wild lettuce mechanism of action

[markosheehan]

Does any one know is wild Lettuce is a anticholinergic?

I have also read it is a adenosine agonist which is interesting as these have a lot of Potential and have not been looked into enough in developing a safer sedative relative to marketed ones maybe.

Also does anyone know if it contains Tropane alkaloids. some people have claimed this but I can not find any scientific study suggesting this.

 

[anubis23]

Yea I can't find anything other than a "trace of hyoscamine" in samples.

Zargari A. Medicinal plants. Tehran University Publications 1978; 3: 223–8

Sounds like a standardized form or derivative would be helpful in agitation in patients with Alzheimers:
https://www.ncbi.nlm.nih.gov/pubmed/16472227

 

[markosheehan]

yes as it is a Acetylcholinesterase inhibitor. i have also read that hyoscamine is not responsible for its psychoactive affects

 

[LandsUnknown]

It's only weakly active. So, an effective extraction of alkaloids would require an unusually large amount of plant material.