I've been only recently searching for an answer to a question I've had for a while now, and i can't seem to find anything on google or in any research paper ive come across, so I'll pose this question to you guys.
I take 3 different serotonin affecting antidepressants (sertraline 200 mg in the morning 50 mg at night, mirtazapine 30 mg, often split into 2 15 mg doses for day and night, and trazadone 300 mg(although taken for sleep, I'm on a dose which is a prescribed dose for depression)). I also get a monthly shot of invega sustenna 234 mg. of course sertraline is a SSRI and i understand how they work, but every day I combine it with mirtazapine, which is a NaSSA which acts as an antagonist at 5ht2a and 5ht2c, and trazadone, another 5ht2a antagonist, and also my invega is always in my system, which has the effect of 5ht2a antagonism. I don't understand all that well how all these serotonergic drugs work in tandem together, but I do know that since I've added mirtazapine to my daily regimen first for sleep, then using half my dose in the morning, I've noticed improved symptom relief and overall an overall increase in mental stability and overall mental health well-being. I also noticed the same effects at night after first having my trazadone raised to 300 mg, then adding 50 mg sertraline, then finally adding at first 30 mg (now 15) mirtazapine at night. Am i over doing my antidepressant regimen and at risk of some serious health issuses, or have i found a perfect balance for me and im not doing harm to my brain? And just how so these meds work together? in very intrigued and look forward to your knowledgeable answers.
In case it matters, I'll list my other medications:
bupropion 450 mg/day
gabapentin 600 mg 3x daily
divalproex sodium ER 1500 mg/night
triazolam 0.5 mg/night
I take 3 different serotonin affecting antidepressants (sertraline 200 mg in the morning 50 mg at night, mirtazapine 30 mg, often split into 2 15 mg doses for day and night, and trazadone 300 mg(although taken for sleep, I'm on a dose which is a prescribed dose for depression)). I also get a monthly shot of invega sustenna 234 mg. of course sertraline is a SSRI and i understand how they work, but every day I combine it with mirtazapine, which is a NaSSA which acts as an antagonist at 5ht2a and 5ht2c, and trazadone, another 5ht2a antagonist, and also my invega is always in my system, which has the effect of 5ht2a antagonism. I don't understand all that well how all these serotonergic drugs work in tandem together, but I do know that since I've added mirtazapine to my daily regimen first for sleep, then using half my dose in the morning, I've noticed improved symptom relief and overall an overall increase in mental stability and overall mental health well-being. I also noticed the same effects at night after first having my trazadone raised to 300 mg, then adding 50 mg sertraline, then finally adding at first 30 mg (now 15) mirtazapine at night. Am i over doing my antidepressant regimen and at risk of some serious health issuses, or have i found a perfect balance for me and im not doing harm to my brain? And just how so these meds work together? in very intrigued and look forward to your knowledgeable answers.
In case it matters, I'll list my other medications:
bupropion 450 mg/day
gabapentin 600 mg 3x daily
divalproex sodium ER 1500 mg/night
triazolam 0.5 mg/night