Ok I browsed through the thread. You're in Canada right? Apparently preg is illegal but people have been ordering off Amazon without issue there.
25mg preg
50mg dhea
Taken sublingually
That seems to be the dose with best response from members on that board (thread is 11 pages and I just speed read through about 60% of it gathering those numbers). Might wanna take it in the Am as lots have reported a stimulated feeling. Genetic Freaks partner posted some studies related to it too I believe so he and she may prove valuable to this topic.
I have for some time attempted to look into hormone synthesis downstream of cholesterol.... (pregnenolone and DHEA)... The enzymatic conversion process is relatively easy to find and understand in normal healthy individuals...
It is the impact caused by exogenous testosterone administration which is proving more difficult... Such as how far negative feedback via GnRH, LH, FSH impacts upstream of testosterone synthesis..? (if indeed it does)..
I'm assuming the negative feedback cannot kick in directly at cholesterol, halting synthesis of all hormones downstream, because otherwise the body would be devoid of such vital hormones such as Aldosterone, Progesterone, and the Glucocorticoids..
Because hormones are synthesised in various tissues and organs of the body, mainly in adrenal gland, but also liver, skin, hippocampus, testes, and retina, I assume synthesis of testosterone cease in the testes but remain via the adrenal gland... Thus leaving the conversion of pregnenolone, DHEA etc converted in other tissues/organs relatively unaffected..
My understanding is that levels of FSH and LH (the only thing that matters when taking exogenous test) only really affect P450scc in the testes. P450scc is the thing that produces pregnenolone from cholesterol, which is thus the rate limiting step in the production of everything else.
FSH and LH have little (I believe) effect on the activity of that enzyme anywhere else. ACTH has more influence, which exogenous test has little effect on. So in that regards, the whole gamut of neurosteroids and derivatives is produced as required in their relevant target tissues.
The same is approximately true for DHEA.
So, in the testes levels will drop to virtually zero with exogenous test, but in the brain and adrenals it's still produced as required. In the case of DHEA, as precursor to natural test and oestrogen, the circulating levels should be considerably lower than pregnenolone when you take exogenous test. Most anti-aging clinics thus supplement with additional DHEA, but there's very little evidence to support raising circulating concentrations given that localised concentrations (eg in the brain) remain elevated so that it can still function as a neurosteroid.
Pregnenolone is banned here in NZ, so no experience there, DHEA sublingual didn't do much for me, but thats same for most things..
