I like a good bit of theoretical knowledge every now and then just for fun, but with that said, I have a hard time finding how this is useful to anyone at this moment. Even if Naloxone (Narcan) were effective by the vaporization route, which it most certainly is and even if it were say, faster in effect than the intranasal route, it would still be impractical because Naloxone is already distributed in simple, easy to use packages. Fumbling around with tin-foil and freebase Naloxone while somebody is actively dying seems like a bad idea, when a dose of life-saving antidote could've already been successfully administered.
But, I also get that what you're after is for research purpose regarding the up/down regulation of Opioid receptors. The next issue I see is that if you're really looking to get the most out of your research per mile, as it were, is that you will be severely limiting the scope of said research by moving to an obscure route of administration that is never used, as opposed to studying the action of Naloxone as it has been used for decades. I just see a lot of potential pitfalls here in what you're trying to accomplish.
I do, however, find information regarding Naloxone and/or Naltrexone's ability to up/down regulate Opioid receptors to be interesting. I would suggest focusing your research on already well-covered routes of administration for the drug. You already have great examples ranging from oral administration to intravenous administration, specifically, the effects when first-pass metabolism are and are not at play. I don't see how information regarding vaporization could be meaningfully different for your purposes.
I'm going to move this to Neuroscience and see what happens though!