JohnBoy2000
Bluelighter
- Joined
- May 11, 2016
- Messages
- 2,468
Working my way through Rang and Dales Pharmacology - on the chapter about anti-epileptics.
The primary mechanism seems to be, blockade of Sodium or Calcium channels, and I think, positive allosteric modulation of - Phosphorous channels??
Looking at pharmaco-dynamic binding profiles of drugs, receptor subtypes - mainly 5HT - seem to be, G-protein coupled.
But then of course there are ionic channel coupled receptor proteins.
So my question: when anti epileptics like, valproic acid or, whatever; when it's mentioned they blocked ion channels, which inhibit membrane hyperpolarization and thus neurotransmitter release.
Is essentially what they're saying is, the drugs are specific to receptor subtypes which are ion channel coupled??
Such as - I don't know - whatever they may be: glutamatergic or the other primary amino acid receptors.
One or two of the 5HT subtypes, etc.
OR.
Are ion channels just, occurring independently of cellular membrane receptor proteins?
And if so - what normally regulates them?
I know by example, the transporter proteins implicated in SSRI's are based on ionic gradients, which would thusly indirectly function on ion channel transmission.
So - there must be a naturally occurring regulatory mechanism of some kind, right?
The primary mechanism seems to be, blockade of Sodium or Calcium channels, and I think, positive allosteric modulation of - Phosphorous channels??
Looking at pharmaco-dynamic binding profiles of drugs, receptor subtypes - mainly 5HT - seem to be, G-protein coupled.
But then of course there are ionic channel coupled receptor proteins.
So my question: when anti epileptics like, valproic acid or, whatever; when it's mentioned they blocked ion channels, which inhibit membrane hyperpolarization and thus neurotransmitter release.
Is essentially what they're saying is, the drugs are specific to receptor subtypes which are ion channel coupled??
Such as - I don't know - whatever they may be: glutamatergic or the other primary amino acid receptors.
One or two of the 5HT subtypes, etc.
OR.
Are ion channels just, occurring independently of cellular membrane receptor proteins?
And if so - what normally regulates them?
I know by example, the transporter proteins implicated in SSRI's are based on ionic gradients, which would thusly indirectly function on ion channel transmission.
So - there must be a naturally occurring regulatory mechanism of some kind, right?