I don't consider SSRIs and SNRIs useful. And other drugs that you have to wate weaks for them to work and after which they don't produce any sufficient/extreme anti-depressant effects like those below.
Also I don't consider useful such drugs with very probable horrific side effects like Sabril (when you can literally go blind from it).
The List:
Benzos (e.g. Alprazolam)
Opiates (Oxycodone, Tramadol etc.)
Pregabalin/ Gabapentin
Ritalin/Adderall (mainly for work as speed. For me not very useful as an anti-depressant)
Bupropion
Tiagabine (GABA Reuptake inhibitor). I read posts from people that have really euphoric effects from it)
Baclofen
Propranolol (may really help with anxiety and without tolerance)
GHB
Russian Pharmaceuticals:
Bromantan (increases Dopamine, Seratonin, Noradrenaline and GABA. Probably the best drug.)
Semax
"In animals, Semax rapidly elevates the levels and expression of brain-derived neurotrophic factor (BDNF) and its signaling receptor TrkB in the hippocampus, and rapidly activates serotonergic and dopaminergic brain systems.In accordance, it has been found to produce antidepressant-like and anxiolytic-like effects,]attenuate the behavioral effects of exposure to chronic stress, and potentiate the locomotor activity produced by D-amphetamine. As such, it has been suggested that Semax may be effective in the treatment of depression, as well as in attention deficit hyperactivity disorder (ADHD)."
Selank
Selank (Russian: Cеланк) is a nootropic, anxiolytic peptide based drug developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. Selank is a heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. It is a synthetic analogue of a human tetrapeptide tuftsin.
In clinical trials, the drug has shown to provide a sustained nootropic and anxiolytic effect which is useful for the treatment of generalized anxiety disorder (GAD).Selank has an advantage over traditional anxiety treatments, such as benzodiazepines, as it has no sedating or negative cognitive side effects and no associated addiction or withdrawal problems.
Afobazol
Fabomotizole is an anxiolytic drug developed in the beginning of 2000s by the Russian Academy of Medical Sciences. The goal of researchers at that time was to create a selective anxiolytic agent that would not have the adverse effects of benzodiazepines. In the open studies, the drug appeared to be as effective for the treatment of generalised anxiety disorder as diazepam, while causing significantly fewer side effects.
The producers of the drug claim that it stabilizes and upregulates GABA and benzodizepame receptors, exhibits neuroprotective properties, and diminishes anxiety and tensions in the body. The drug is designed above all for people with asthenic personal traits such as emotianal lability, e.g. tendency to react emotionally to stressful situations.
Meldonium
Noopept
Phenibut
And many other greate drugs that are available on Russian store websites, which you can look up for youself.
Nootropics/Suplements:
Phosphaditilserine, Omega fats, DL-Phenylalanin, Tyrosin, L-Theanin, 5-HTP + Green Tea Extract, ALCAR, L-Carnitine.
L-Tryptophan, B-Complex, Magnesium, Zinc Picolinate, Brahmi, Lecithin, Maca, Guarana, Lemon Balm, Velerian Root, Skullcap, Baicalin, Chamomile etc.
Did I missed something? Does anyone know some other good stuff, I'm interested mainly in the western pharmaceuticals ?
Also I don't consider useful such drugs with very probable horrific side effects like Sabril (when you can literally go blind from it).
The List:
Benzos (e.g. Alprazolam)
Opiates (Oxycodone, Tramadol etc.)
Pregabalin/ Gabapentin
Ritalin/Adderall (mainly for work as speed. For me not very useful as an anti-depressant)
Bupropion
Tiagabine (GABA Reuptake inhibitor). I read posts from people that have really euphoric effects from it)
Baclofen
Propranolol (may really help with anxiety and without tolerance)
GHB
Russian Pharmaceuticals:
Bromantan (increases Dopamine, Seratonin, Noradrenaline and GABA. Probably the best drug.)
Semax
"In animals, Semax rapidly elevates the levels and expression of brain-derived neurotrophic factor (BDNF) and its signaling receptor TrkB in the hippocampus, and rapidly activates serotonergic and dopaminergic brain systems.In accordance, it has been found to produce antidepressant-like and anxiolytic-like effects,]attenuate the behavioral effects of exposure to chronic stress, and potentiate the locomotor activity produced by D-amphetamine. As such, it has been suggested that Semax may be effective in the treatment of depression, as well as in attention deficit hyperactivity disorder (ADHD)."
Selank
Selank (Russian: Cеланк) is a nootropic, anxiolytic peptide based drug developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. Selank is a heptapeptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro. It is a synthetic analogue of a human tetrapeptide tuftsin.
In clinical trials, the drug has shown to provide a sustained nootropic and anxiolytic effect which is useful for the treatment of generalized anxiety disorder (GAD).Selank has an advantage over traditional anxiety treatments, such as benzodiazepines, as it has no sedating or negative cognitive side effects and no associated addiction or withdrawal problems.
Afobazol
Fabomotizole is an anxiolytic drug developed in the beginning of 2000s by the Russian Academy of Medical Sciences. The goal of researchers at that time was to create a selective anxiolytic agent that would not have the adverse effects of benzodiazepines. In the open studies, the drug appeared to be as effective for the treatment of generalised anxiety disorder as diazepam, while causing significantly fewer side effects.
The producers of the drug claim that it stabilizes and upregulates GABA and benzodizepame receptors, exhibits neuroprotective properties, and diminishes anxiety and tensions in the body. The drug is designed above all for people with asthenic personal traits such as emotianal lability, e.g. tendency to react emotionally to stressful situations.
Meldonium
Noopept
Phenibut
And many other greate drugs that are available on Russian store websites, which you can look up for youself.
Nootropics/Suplements:
Phosphaditilserine, Omega fats, DL-Phenylalanin, Tyrosin, L-Theanin, 5-HTP + Green Tea Extract, ALCAR, L-Carnitine.
L-Tryptophan, B-Complex, Magnesium, Zinc Picolinate, Brahmi, Lecithin, Maca, Guarana, Lemon Balm, Velerian Root, Skullcap, Baicalin, Chamomile etc.
Did I missed something? Does anyone know some other good stuff, I'm interested mainly in the western pharmaceuticals ?
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