Neuroprotection
Bluelighter
- Joined
- Apr 18, 2015
- Messages
- 1,088
According to some reports, the hormone/neurotransmitter Melatonin can prevent the development of tolerance to many psychoactive drugs. In addition it supposedly reverces tolerance completely once it has occurred. The drugs most affected by Melatonin are the Stimulants, benzodiazepines and opioids. According to one study Melatonin could enhance the rewarding affects of Morphine in rats possibly due to suppression of Neuronal Nitric Oxide Synthase (NOS). This is without providing its own psychoactive affects and polluting the experience. This is however a common problem with trying to use NMDA antagonists to potentiate opioids and reduce tolerance. Of course this may seem to good to be true, but it may provide a lead for development of small molecules that could stop and reverce tolerance for good. I have already posted a similar thread long ago which focused on Benzodiazepine tolerance, so sorry if it seems like I am repeating the same topic.
I would be very grateful if anyone who has combined Melatonin with other drugs could post their experience.
What do you all think
I would be very grateful if anyone who has combined Melatonin with other drugs could post their experience.
What do you all think