First off I'm a medic and don't recommend you mixing NSAIDs (especially acetaminophen) with ETOH (ethyl alcohol - just in case a reader is unfamiliar with the abbreviation). Also on top of my experience in the field and hospitals my wife almost died of liver failure a few years ago due to ETOH alone so let me fill you in a bit about what liver failure is like and why it's not worth the risk: Elephant in the room - yes the liver is the only organ that can regenerate but this is limited to the amount of damage, too much and it's over.
SO: If experiencing acute ETOH/drug induced hepatitis (inflamation of the liver - not to be confused with viral hepatitis A/B/C etc.) you will likely start with severe upper abdominal pain maybe radiating to the back. As the liver stops working it will also stop processing bilirubin which will cause levels to rise and turn you into a simpsons character which we call jaundice. First it will be the whites of your eyes and then all of you. As your liver fails to perform it will stop producing albumin. Albumin is a large molecule that keeps fluid in the vasculature due to it's oncotic pull. When these levels drop fluid starts escaping into 2nd and 3rd space causing edema in the lower extremities and distention of the abdomen as fluid is lost from venous/arterial space quicker than the lymphatic system can put it back. You will end up with this abdominal distention (ascites) and require a procedure called a paracentesis - this is a huge ass needle put into the abdominal space (while you are awake) to drain excess fluid. The issues with your liver can also lead to pancreatitis, renal failure, heart failure, and everything else nasty you can imagine. Ammonia levels will rise causing hepatic encephalopathy of the brain meaning you'll not mentate properly and at this point maybe won't care that you're dieing, but you are. After a week in hospital I was told my wife had mayb 48 hours of consciousness and would likely die within 5 days afterward. There will be enough time for you to see your family members and say goodbye but by then the brain swelling and amount of opiates you need for pain control will make it meaningless - for you. Barring all of the scopes put either up your ass or down your thoat, poking, prodding, Rx and side-effects, you will die slow enough for the people around you to watch. It's not an easy out, and as an addict you don't qualify for transplant - even if a family member wanted to donate they will not risk two lives to save one (at least here). It's a long, slow, and painful death - which is why I always warn teenage girls I encounter in distress against tylenol OD. It seemed to be popular with girls when I was in high school but they didn't realize that doing so wouldn't kill them right away. It would kill them in a week, or a month. Long after they've had time to reconside things after it's too late.
I know you say "once in a while" but don't take chances on that. It's no joke, and it's a shitty way to go. My wife survived btw - after I'd told her she was going to die in two days they threw a hail mary and she responded and is doing well (not great, but well). When she was discharged the admitting ER doc saw her and it looked like he'd seen a ghost. She was lucky, most people aren't. There were a few times that my 24hr observation and diligence saved her because I've been in medicine for almost a decade. If not for that she likely would not have made it. If you don't have that kind of support I wouldn't recommend toying with your liver. I wouldn't recommend toying with anything TBH but I just thought I'd give you a healthy dose of reality before you take your next toxic hepatic dose of ETOH and painkillers.
Wishing you all the best. I hope you and your loved ones never have to go through what I just described. I'm not just posting this for you, but for everyone who reads it taking the liver lightly. Don't. You need it to live and it's failure will affect other organs you also need to live. Years after we still have to get fibroscans and a few weeks ago she was hospitalized for acute pancreatitis which again almost killed her as an after effect of her ETOH use alone. Don't play, take it from a man who's watched many people leave this world. There's only one life, and although I'm not terribly spiritual I will say that you can see the moment when the life leaves someones eyes. Live long, live healthy, and don't risk your health for an escape. I've never heard anyone on their death bed wish that they had lived less. Go out there and live your life, don't hide behind the drink, or the drug, or whatever your vice. You only get one go at it so make it a good one.
Cheers, I hope this helps you, or at least someone else reading it.
