Do you have to develope tolerance to antidepressant effects of DRIs?
I asked something similar in a similar thread, but I didn't got satisfactory answer so I want to take it from another angle.
I'm curious about Dopamine Reuptake Inhibitors and why more drugs of that class are not developed for depression and other purposes. The answer that I've got is that in the early time of psychiatry people thought that amphetamin is an anti-depressant and because of consant tolerance growth and need of dosage increase they resign from it. But DRIs are not like amphetamine bacause you don't really build up tolerance to them, usually. For example Ritalin is a drug that can be used for years without (almost) any tolerance. The only problem is that this drug is too egdy and couse anxiety. It's nothing like meth or cocke.
But I know there are other selective DRIs that are euphoric like Desoxypipradril and others.
So my my question is: Do you build up tolerance to the drug or to the Euphoria coused by a DRI when using it everyday?
Does anyone used such drugs like Desoxypipradril or others euphoriant DRIs everyday? If you don't develope tolerance to the drug but to euphoria do you develope than complete tolerance to euphoria? Is it possible to take something like Desoxypipradril and have anti-depressant effects from it for years?
Or if you develope partial tolerance to euphoria can such kind of drug be a benefit for depression even if partial tolerance has developed?
I asked something similar in a similar thread, but I didn't got satisfactory answer so I want to take it from another angle.
I'm curious about Dopamine Reuptake Inhibitors and why more drugs of that class are not developed for depression and other purposes. The answer that I've got is that in the early time of psychiatry people thought that amphetamin is an anti-depressant and because of consant tolerance growth and need of dosage increase they resign from it. But DRIs are not like amphetamine bacause you don't really build up tolerance to them, usually. For example Ritalin is a drug that can be used for years without (almost) any tolerance. The only problem is that this drug is too egdy and couse anxiety. It's nothing like meth or cocke.
But I know there are other selective DRIs that are euphoric like Desoxypipradril and others.
So my my question is: Do you build up tolerance to the drug or to the Euphoria coused by a DRI when using it everyday?
Does anyone used such drugs like Desoxypipradril or others euphoriant DRIs everyday? If you don't develope tolerance to the drug but to euphoria do you develope than complete tolerance to euphoria? Is it possible to take something like Desoxypipradril and have anti-depressant effects from it for years?
Or if you develope partial tolerance to euphoria can such kind of drug be a benefit for depression even if partial tolerance has developed?
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