Since I'm able to read German up to a point, I did read the German wiki for clonazepam.
The information was a bit different from what I'd gotten earlier.
https://de.wikipedia.org/wiki/Clonazepam Ein kleiner Teil wird chemisch umgebaut und dann erst ausgeschieden. Die Plasmahalbwertszeit beträgt etwa 30–40 Stunden.[3] Der Anteil, der an die Eiweißmoleküle im Blut gebunden ist (Plasmaproteinbindung), liegt bei 83–87 %, die Bioverfügbarkeit bei 71–76 %. Es wirkt über die verstärkte Hemmung GABAerger Nervenzellen und bindet am GABAA-Rezeptor.
A bioavailability of 71-76 %, not the same as medsafe.govt.nz/profs/Datasheet/r/Rivotriltabdropinj.pd
Checking wiki's definition of bioavailability, 'In pharmacology, bioavailability (BA) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. By definition, when a medication is administered intravenously, its bioavailability is 100%.[1] However, when a medication is administered via other routes (such as orally), its bioavailability generallyTH[›] decreases (due to incomplete absorption and first-pass metabolism) or may vary from patient to patient. Bioavailability is one of the essential tools in pharmacokinetics, as bioavailability must be considered when calculating dosages for non-intravenous routes of administration.'
So if I understand correctly, a very large part does not reach the CNS. Why would this be so ? Especially, since diazepam's bioavailability is 100 % (oral).
Is anyone able to get me the German PI sheet for Rivotril ? Apparently, it's not for public use ...
Sorry about the messy format, I can't get it fixed.
The information was a bit different from what I'd gotten earlier.
https://de.wikipedia.org/wiki/Clonazepam Ein kleiner Teil wird chemisch umgebaut und dann erst ausgeschieden. Die Plasmahalbwertszeit beträgt etwa 30–40 Stunden.[3] Der Anteil, der an die Eiweißmoleküle im Blut gebunden ist (Plasmaproteinbindung), liegt bei 83–87 %, die Bioverfügbarkeit bei 71–76 %. Es wirkt über die verstärkte Hemmung GABAerger Nervenzellen und bindet am GABAA-Rezeptor.
A bioavailability of 71-76 %, not the same as medsafe.govt.nz/profs/Datasheet/r/Rivotriltabdropinj.pd
Checking wiki's definition of bioavailability, 'In pharmacology, bioavailability (BA) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. By definition, when a medication is administered intravenously, its bioavailability is 100%.[1] However, when a medication is administered via other routes (such as orally), its bioavailability generallyTH[›] decreases (due to incomplete absorption and first-pass metabolism) or may vary from patient to patient. Bioavailability is one of the essential tools in pharmacokinetics, as bioavailability must be considered when calculating dosages for non-intravenous routes of administration.'
So if I understand correctly, a very large part does not reach the CNS. Why would this be so ? Especially, since diazepam's bioavailability is 100 % (oral).
Is anyone able to get me the German PI sheet for Rivotril ? Apparently, it's not for public use ...
Sorry about the messy format, I can't get it fixed.