how does CHIRALITY, ISOMERS etc affect REAGENT test results?

[lab slave]

Ok I haven't seen this answered anywhere else, hope someone can help me out.

Do test kits respond differently to different stereoisomers?

I know that many popular recreational drugs in fact appear in two or more versions with the same molecular formula. Famously "dexamphetamine" is only the right-handed amphetamine molecule. Ketamine also comes in two versions, the most active version is S-ketamine or esketamine.

This question arose parlty because it seems methoxetamine(MXE) is occasionally being sold as ketamine in this city. Unfortunately there doesn't seem to be a definitive reagent test for MXE, there are conflicting pics circulating online about MXE responding to the mandelin reagent. So the obvious theory would be that mxe and possibly K also react differently depending on the isomers present.

What do you guys think? Good theory or bad?

Also what's the best reagent to test for this class of drugs (possibly a more difficult question)?

 

[Glubrahnum]

Do test kits respond differently to different stereoisomers?

The conventional chemistry and physics say "no, they are not stereoselective" unless the reagent contains chiral molecules or is illuminated by a polarized light.
For example the Marquis reagent contains sulfuric acid and formaldehyde, which cannot be chiral.

 

[Transform]

The froedhe reagent can effectively distinguish MXE from ketamine, as it makes methoxetamine go yellow-green but ketamine does not cause a colour change.