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by Derek Beres: big think
LSD reached America thanks to schizophrenia. Though Albert Hoffman mistakenly synthesized the potent psychedelic in 1938 in Switzerland, it wasn’t until Viennese doctor Otto Kauders told a group of mental health professionals about the substance’s ability to drive one “temporarily crazy” in 1949 that researchers began listening. German refugee Max Rinkel immediately ordered a shipment from Hoffman’s company.
Interestingly, psychiatrist Robert Hyde decided to conduct his normal hospital rounds after ingesting the first American dose. He grew irritated, believing to have received a bunk dose. Problem is, Hyde was normally a pleasant man. He might not have achieved a schizophrenic state (his dose was rather low), but the LSD certainly had an emotional effect.
The government jumped aboard. The CIA’s covert Project MKUltra was instituted in hopes of manipulating Russian spies to spill secrets. Officially sanctioned in 1953 (though trials began earlier), for two decades the US government secretly dosed a range of unsuspecting mental health patients, prostitutes, drug addicts, and prisoners in attempts of discovering LSD’s abilities.
Possession of LSD became illegal in 1968; the last sanctioned FDA study on its effects took place 12 years later. Being categorized as a Schedule 1 drug (no medical value), few researchers were willing to touch it. But a recent uptick in studies have found that LSD is not medically useless. It is being tested in treatment programs for alcoholics and drug abusers. Microdosing has become a certified fad. And a recent study published in Nature found LSD might help you regulate your emotions.
Twenty healthy participants with no or minimal (one time only) experience with psychedelics ingested either 100μg LSD or a placebo. They were then shown fearful or neutral faces while undergoing brain scans. Three brain regions were focused on: the amygdala, the seat of emotional processing, along with the fusiform gyrus and medial frontal gyrus, both areas that are responsive to fearful faces.
The researchers’ hypothesis proved correct: LSD reduced amygdala activity. Those who took the substance were less emotionally volatile in response to fearful faces. To test against the possibility that the psychedelic effects distorted faces, researchers cite a similar response in subjects receiving 200μg LSD to fearful faces, who experienced no alteration in the recognition of neutral, happy, or angry faces.
This leads researchers to believe that LSD might help people suffering from anxiety disorder and depression. By “reducing perception of negative emotions and social cognitive deficits,” LSD could soon find widespread usage in the psychiatrist’s arsenal of remedies. Of course dose and mental history are important factors, but so far the results are positive.
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LSD reached America thanks to schizophrenia. Though Albert Hoffman mistakenly synthesized the potent psychedelic in 1938 in Switzerland, it wasn’t until Viennese doctor Otto Kauders told a group of mental health professionals about the substance’s ability to drive one “temporarily crazy” in 1949 that researchers began listening. German refugee Max Rinkel immediately ordered a shipment from Hoffman’s company.
Interestingly, psychiatrist Robert Hyde decided to conduct his normal hospital rounds after ingesting the first American dose. He grew irritated, believing to have received a bunk dose. Problem is, Hyde was normally a pleasant man. He might not have achieved a schizophrenic state (his dose was rather low), but the LSD certainly had an emotional effect.
The government jumped aboard. The CIA’s covert Project MKUltra was instituted in hopes of manipulating Russian spies to spill secrets. Officially sanctioned in 1953 (though trials began earlier), for two decades the US government secretly dosed a range of unsuspecting mental health patients, prostitutes, drug addicts, and prisoners in attempts of discovering LSD’s abilities.
Possession of LSD became illegal in 1968; the last sanctioned FDA study on its effects took place 12 years later. Being categorized as a Schedule 1 drug (no medical value), few researchers were willing to touch it. But a recent uptick in studies have found that LSD is not medically useless. It is being tested in treatment programs for alcoholics and drug abusers. Microdosing has become a certified fad. And a recent study published in Nature found LSD might help you regulate your emotions.
Twenty healthy participants with no or minimal (one time only) experience with psychedelics ingested either 100μg LSD or a placebo. They were then shown fearful or neutral faces while undergoing brain scans. Three brain regions were focused on: the amygdala, the seat of emotional processing, along with the fusiform gyrus and medial frontal gyrus, both areas that are responsive to fearful faces.
The researchers’ hypothesis proved correct: LSD reduced amygdala activity. Those who took the substance were less emotionally volatile in response to fearful faces. To test against the possibility that the psychedelic effects distorted faces, researchers cite a similar response in subjects receiving 200μg LSD to fearful faces, who experienced no alteration in the recognition of neutral, happy, or angry faces.
This leads researchers to believe that LSD might help people suffering from anxiety disorder and depression. By “reducing perception of negative emotions and social cognitive deficits,” LSD could soon find widespread usage in the psychiatrist’s arsenal of remedies. Of course dose and mental history are important factors, but so far the results are positive.
link
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