I've always been curious about the various nootropics out there, and why people swear by this drug or another. So here I am, writing a practice essay about what the hell is going on with Alzheimer's treatments (I'm just finishing off my pharmacology degree) and come across the mention of a drug called 'Tenilsetam'.
Does anyone know anything about its use? Has anyone used it? Heard of it even? – there is no mention of it anywhere, a number of papers on in vitro/in vivo, a handful of patient studies, but no "records" of anyone using it
It's an AGE (Anvanced Glycation End Product) inhibitor and acts as a nootropic. 1989 was a hot year for testing it in Alzheimer's (AD), but since then, there is barely any information on it. That said, they saw some cognitive improvement and better memory recall, also saw cognitive improvements in control experiments.
Does anyone know "what's wrong with it"? Testing stopped a while back, does it not work? I was surprised to have never heard about it before. Supposedly it shifts brain activity towards low serotonergic and high dopaminergic (in rats, but healthy rats became morevigilant, Wilfried et al., 1989, plus it's been used in people and seems to have worked too). Anybody out there who can fill me in on what happened to the drug?
Apologies if this post is out of place (it's my first post), but I can't help being curious whether there's anyone out there who has actually used it
Oh and, if there are any other random nootropics you can think of, please throw them my way (Too many dementia patients swear by complementing whatever treatment/or lack of thereof by nootropics, it's interesting to read given all the clinical trial failures in the field)
For reference: AD findings – Improvement in favourability judgement task (Perisic et al., 1989), Specific psychomotor improvements (Saletu et al., 1989), Reduced cholinergic deficiency in the hippocampal area, memory improvements (Dierks et al., 1989)
Does anyone know anything about its use? Has anyone used it? Heard of it even? – there is no mention of it anywhere, a number of papers on in vitro/in vivo, a handful of patient studies, but no "records" of anyone using it
It's an AGE (Anvanced Glycation End Product) inhibitor and acts as a nootropic. 1989 was a hot year for testing it in Alzheimer's (AD), but since then, there is barely any information on it. That said, they saw some cognitive improvement and better memory recall, also saw cognitive improvements in control experiments.
Does anyone know "what's wrong with it"? Testing stopped a while back, does it not work? I was surprised to have never heard about it before. Supposedly it shifts brain activity towards low serotonergic and high dopaminergic (in rats, but healthy rats became morevigilant, Wilfried et al., 1989, plus it's been used in people and seems to have worked too). Anybody out there who can fill me in on what happened to the drug?
Apologies if this post is out of place (it's my first post), but I can't help being curious whether there's anyone out there who has actually used it
Oh and, if there are any other random nootropics you can think of, please throw them my way (Too many dementia patients swear by complementing whatever treatment/or lack of thereof by nootropics, it's interesting to read given all the clinical trial failures in the field)
For reference: AD findings – Improvement in favourability judgement task (Perisic et al., 1989), Specific psychomotor improvements (Saletu et al., 1989), Reduced cholinergic deficiency in the hippocampal area, memory improvements (Dierks et al., 1989)
