[h=3]Durela? (Canada)/ConZip? (US)[/h]Durela? (CIP-Tramadol), manufactured by Cipher Pharmaceuticals Inc. (Mississauga, Ontario, Canada), is available as 100 mg, 200 mg, and 300 mg extended-release capsules in Canada and the US. The Durela manufacturing technology is novel and unique. The Durela capsules are comprised of an immediate-release tablet and multiple extended-release beads. The extended-release beads consist of a Tramadol core covered with a microporous polymer membrane. All beads are similar and each of them may be considered an individual controlled release system. As the Durela capsule dissolves in the stomach, water crosses the membrane and penetrates into the beads. The water then dissolves a fraction of the Tramadol content and the solute is released from the bead into the gut by osmotic pressure. As this process continues, Tramadol is progressively released at a constant rate until the bead core is depleted of its Tramadol content (
Figure 2).
43 The microporous insoluble membrane properties are not affected by the gastrointestinal environment, eg, pH, amount of water, fat content, or peristaltic motility of the gastrointestinal tract (
Figure 3). This effect is the mechanism that gives Durela its independence from food effect. ?All strengths of Durela capsules have been reported to be dose proportional over the 100?300 mg range?.
31,
43 The pharmacokinetic profile describes the presence of a dual mode of action with Durela extended-release capsules. The immediate-release component in Durela capsules provides the same onset of analgesia as seen with immediate-release Tramadol products. This is followed by the extended-release component of the capsules which provides a consistent release of Tramadol throughout the 24-hour dosing cycle. In one single-dose study comparing Durela (CIP-Tramadol ER) 300 mg capsules versus 300 mg of a marketed formulation of extended-release Tramadol, Durela C
max were above 110 ng/mL at 1 hour post-dosing and above 191 ng/mL at the end of 24 hours post-dose.
This may not be the same medication but was all I could find.
I would not abuse this medication.