Either address the responses, markosheehan, or the thread gets closed.
This is not a one-way street and we're not here to enable you, that would be bad HR.
If you recall I've expressed the same suspicion / concerns in another thread and/or PM by the way, so it's really starting to get hard to avoid it.
LSD is usually taken in a much smaller dose than other drugs. 1 gram of LSD is more toxic than 1 gram of weed
i am sorry solipsis i do not understand what you are saying here?
Last edited by markosheehan; 21-04-2017 at 16:08.
"LSD is able to suppress the proliferation of B-lymphocytes; the production of the cytokines IL-2, IL-4, and IL-6; and the induction of cytotoxic T-lymphocytes at a concentration of 100 microM."
So from this line i am guessing it is a bad thing because its good to have B-lymphocytes to defend against infection. And as it says It was in a concentration of 100 mics so within the human dosage.
So from this It COULD be bad for your immune system
Last edited by markosheehan; 21-04-2017 at 17:22.
Nonetheless, that doesn't prove that there's any negative consequences to this.
Going back a bit....
The exact same thing can be true with the kind of toxicity you speak of. The threshold may be lower than a recreational dose, but it may not be, and you shouldn't just assume it is without good reason.
Ultimately, the point is, even if there actually is some theoretical risk that can be seen by looking at the microscopic level, the actual consequences seem to be so insignificant that it barely even seems worth discussing, and definitely isn't worth letting yourself worry over.
I know it does not prove it. thats why i used the word "could". Its definately not a good sign though even though it could be insignificant due to high concentrations of LSD not being present in your body for long as its broken down like the study mentions.
How do you know mutations and genetic damage works like this? any sources?
Im well aware of how long LSD has been around and I do take this into account however drugs before have caused toxicity but It can be hard to detect due to integration into other things aswell as a load of other factors.
I do have to say though its safety profile is quite amazing. However it is still interesting ( for me at least) to look at theoretical risk
I have been thinking about drugs and the immune system and even if a drug does harm your immune system its usual only temporary so unless you are taking it a lot it would not put you at much risk to being prone to disease.
It is pointless to discuss what a compound does when you take an extremely massive overdose because it doesn't say anything about safety when taking a normal reasonable dose.
Focussing too much on such things and completely failing to reply to people pointing out this significance / relevance, people who point out how relative things are... that is what prompts people to be concerned about hypochondria.
In the NSP forum you can talk all you want about theoretical data of studies, but if it applies to consideration of risks for your own use, not theory but reality discussed here in PD, you should confront the fact that no drug use is 100% without risk and it is pointless looking for it. If you cannot accept this, don't use drugs. If you can accept it, be satisfied with the facts you have already gathered on things like LSD and psilocin/mushrooms.
It's fine collecting information, but it's not healthy to do it in the way you conduct it. So, the choice I give you is: address these issues or we have to stop this. It's not right to just go on and on.
100 µM is micromolar, not micrograms. it's a concentration not a dose - so your question or concern is not applicable.
Oh, kaleida already mentioned this.
So again: let's discuss the obsessive aspect a bit, the small significance of the issues you are looking for. Again and again they suggest how relatively safe things like LSD are considered to be, yet you are on a witchhunt to find damning evidence that somehow slipped through the cracks and goes unnoticed.
Why don't you just start a thread in NSP asking about the worst risks of LSD and psilocin known, and see what knowledgeable people have to say? Seems way better than trying to interpret scientific articles as a layman. It's a waste of time for your fellow PDers.
We're open to talking about real and relevant risks but there is another way to go about that than your current approach.
"These results demonstrate that LSD may have a direct effect on components of the immune system at concentrations that may be reached upon human exposure."
Haha sounds like we are closing...
This thread is ruining my strategic popcorn reserve.
What I will say is:
Some psychedelics like certain 2C-X have been observed to apparently act on the immune system, for example causing production of mucus. As far as I know it is unknown whether there is anything lasting about it but it doesn't seem to be and there is no reason to assume that it is serious either. The effects seem to be in the realm of activation of the immune system rather than suppressing it.
Similarly some drugs other than psychedelics (think opioids and I believe benzos for example, but iirc also alcohol) are known to suppress the immune system. Both activation and suppression aren't ideal of course, activation is at the very least potentially inconvenient, but suppression seems worse since you neither want your immune sytem to get lazy (seen in children raised in an environment that is too clean so the immune system gets little exercise) nor do you want pathogens to get a foot in the door and make you ill.
Other than that, not sure if much at all is known about immunomodulation, just search the internet and bluelight.
I think we have established that a normal dose of LSD is not mutagenic.
to avoid this in the future, don't ignore the posts of others, this is a discussion forum, not quora.
Also: resort to the neuroscience & pharm forum for examination of studies and theoretical implications. It's just not suitable for PD.