I've done two ayahuasca ceremonies and they were very powerful and helped me a lot with a number of my issues. Unfortunately, one of my issues was alcoholism and I have since relapsed. Due to this relapse, my doctor has me on naltrexone, a drug to curb alcohol cravings. It is an opioid antagonist. I am looking to do another two ceremonies at the end of March. However, I have not read much about naltrexone interaction with ayahuasca. I am well aware you can't be on MAO-Is or SSRIs. If anyone has any information on naltrexone, any help would be greatly appreciated.
u/0catfish0 (reddit)
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Naltrexone or Naloxone will not have a drug interaction with Ayahuasca. The opiate receptors that are 'plugged' by Naltrexone are not probably not implicated in Ayahuasca drug effects.
However, I don't know of any clinical studies that support my claim as this is just speculation. It's absolutely possible there there is some relationship between GABA and Glutamate and Ayahuasca but I don't know if that's been studied extensively or at all.
-YogiBarelyThere (reddit)
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Painkillers synthesized from thebaine (buprenorphine, etorphine, oxycodone, oxymorphone, nalbuphine, naloxone, naltrexone) should also be regarded as highly dangerous to combine with MAOIs.
http://sananda-wasi.com/meds-to-avoid-with-ayahuasca/