Foreigner
Bluelighter
- Joined
- Mar 18, 2009
- Messages
- 8,303
I've already UTFSE and have had limited info about my question -- plus the threads were old.
I'm considering asking my doctor for an RX for low dose naltrexone, probably in the 2-4mg range. My intention is to see if it would help my auto-immune condition. People with autoimmune have a dysfunctional ratio of the different kinds of T lymphocytes, and the endorphin up-regulation may help stabilize the immune system along with the inflammatory response.
What I'm researching intensely is the dosage ratio. Most people report success in the 1-4mg range. A lot of people start at 1mg and then upgrade to a max of 4mg. Apparently beyond 4mg it doesn't work the same. The immuno-modulatory effect is at 4mg and below. Some people talk about ultra low dose regimens, like below 0.5mg, but this seems a bit preposterous to me. Any thoughts on dosage?
Could I please get some correction on this from anyone with expertise? ---> My understanding is that the low dose antagonizes opiate receptors, in turn causing them to upregulate / increase growth. (I am thinking this could be similar to how low dose ketamine acts on pre-frontal synapses.) The body responds by increasing endorphin release, which has an immuno-modulatory effect. There is a correlation (causation not yet understood though) between people with low endorphin output and dysregulated immune systems. Am I correct in my understanding?
My other question is... if you're doing LDN and suddenly stop, are one's opiate receptors going to suddenly get flooded by endorphins, causing down-regulation again? What I'm wondering is, IF the drug works for my intended purposes, would I have to be on it forever?
Low doses are cheap and non-toxic so it's worth a try. I am just having a hard time finding definitive research. Big Pharma doesn't care about it anymore because it's off-patent, so most of the reporting is anecdotal from individuals who post their stories online. Some stories are miraculous, frankly.
Any experience or theoretical insight would be GREATLY appreciated as I am about to become my own guinea pig. Wanting to gather as much info as possible before the attempt, and I may post an experience report later.
Thanks!!
I'm considering asking my doctor for an RX for low dose naltrexone, probably in the 2-4mg range. My intention is to see if it would help my auto-immune condition. People with autoimmune have a dysfunctional ratio of the different kinds of T lymphocytes, and the endorphin up-regulation may help stabilize the immune system along with the inflammatory response.
What I'm researching intensely is the dosage ratio. Most people report success in the 1-4mg range. A lot of people start at 1mg and then upgrade to a max of 4mg. Apparently beyond 4mg it doesn't work the same. The immuno-modulatory effect is at 4mg and below. Some people talk about ultra low dose regimens, like below 0.5mg, but this seems a bit preposterous to me. Any thoughts on dosage?
Could I please get some correction on this from anyone with expertise? ---> My understanding is that the low dose antagonizes opiate receptors, in turn causing them to upregulate / increase growth. (I am thinking this could be similar to how low dose ketamine acts on pre-frontal synapses.) The body responds by increasing endorphin release, which has an immuno-modulatory effect. There is a correlation (causation not yet understood though) between people with low endorphin output and dysregulated immune systems. Am I correct in my understanding?
My other question is... if you're doing LDN and suddenly stop, are one's opiate receptors going to suddenly get flooded by endorphins, causing down-regulation again? What I'm wondering is, IF the drug works for my intended purposes, would I have to be on it forever?
Low doses are cheap and non-toxic so it's worth a try. I am just having a hard time finding definitive research. Big Pharma doesn't care about it anymore because it's off-patent, so most of the reporting is anecdotal from individuals who post their stories online. Some stories are miraculous, frankly.
Any experience or theoretical insight would be GREATLY appreciated as I am about to become my own guinea pig. Wanting to gather as much info as possible before the attempt, and I may post an experience report later.
Thanks!!