WARNING: Potentially lethal 3-Meo-PCP batch circulating
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I have analyzed a 3-MeO-PCP batch coming from China a few days ago with the following results:
The sample of supposed 3-MeO-PCP hydrochloride was analyzed by 1H NMR in CDCl3 and D2O. It was found to contain 3% piperidine HCl, 41% PCC HCl and 56% 3-MeO-PCP HCl.
PCC is 1-(piperidin-1-yl)cyclohexane-1-carbonitrile, the most common PCP precursor, formed by reacting piperidine with cyclohexanone and cyanide under appropriate conditions.
The nitrile group is a leaving group in the next reaction step, usually a Grignard reaction. PCC can release cyanide both invivo and in vitro and has been linked to numerous PCP deaths in the past, although the amounts needed to kill are quite high. Considering the lower potency of 3-MeO-PCP (compared to PCP) and the really high amount of PCC in the given sample, the danger of fatal accidents is higher than with usual contaminated PCP batches.
I was asked to post this warning. This batch was originally sent from a well known Chinese vendor. Some of you may not be aware, but most of the Chinese vendors that are left by now do not actually synth their products themselves, but they buy them from big factories that supply various vendors.
It's hard to say how many such factories are operating in China, but probably only very few.
Because of that chances are high that other vendors have also been supplying this batch already. The vendor was informed and they said they will repurify the batch. This might or might not happen, as is so often the case with the Chinese.
So people please be careful and if your vendor can not supply an up to date NMR of his 3-MeO-PCP (which probably 95% of all vendors can not do), then rather not purchase this product! If you research 3-MeO-PCP and notice that it is much lower potency than it should be, then it is very likely that you have this specific batch in hand!
Here are the NMR files:
NMR in D2O:
https://ufile.io/zra4t
NMR in CDCl3:
https://ufile.io/7z3nr
TLDR: A possibly large batch of 3-MeO-PCP was supplied to the market which is only around 56% pure and contains 41% of a potentially lethal impurity (PCC)!
If you research with new 3-MeO-PCP and notice that it is low potency DO NOT just take more of the supposedly impure product because it can KILL YOU!!!