Seppi
Bluelighter
- Joined
- Feb 22, 2014
- Messages
- 294
Unless there's a clinically significant interaction effect between an adverse drug effect of amphetamine and an associated adverse health effect of resistance exercise, that's simply not true.
The prescription of amphetamine to individuals with a structural heart defect is an absolute contraindication for that drug (i.e., a doctor should never prescribe amphetamine to an individual with a heart defect). For healthy individuals without structural defects, two USFDA-commissioned studies with massive sample sizes (n1=1,200,000; n2=440,000) found that the incidence of stroke, heart attacks, and cardiac arrest does not differ between individuals of any age who use amphetamine at clinically-relevant doses and the rest of the population. Moreover, resistance exercise is not a contraindication of amphetamine use according to any national drug regulatory agency or intergovernmental chemical safety agency, so advising people not to engage in resistance exercise while using therapeutic doses of amphetamine is just blatant quackery.
Given that the blood pressure response during resistance exercise is much, much more pronounced than the effect of amphetamine on blood pressure, I'd suspect that the relative risk of a experiencing a hemorrhagic stroke would be higher from performing resistance exercise than taking a clinical dose of amphetamine; however, that would likely only be a potential risk for individuals who suffer from chronic high blood pressure (i.e., individuals who have been diagnosed with hypertension).
That said, there are definitely major concerns associated with concurrent use of amphetamine or other psychostimulants at high/recreational doses and performance of resistance exercise; this is because there is a serious risk of adverse cardiovascular events at very high amphetamine doses, in addition to other overdose symptoms such as rhabdomyolysis and hyperpyrexia, which would likely be exacerbated by resistance exercise.
With respect to the increase in perspiration mentioned by some people in this thread, all amphetamine does to produce this effect at clinical doses is raise the core temperature limit, and I want to again re-emphasize the word "limit" in that statement. Amphetamine doesn't cause an increase in body temperature at clinical doses, but it does allow core body temperature to rise higher than it normally would when physiological conditions (e.g., hot weather, exercise, etc.) would cause it to elevate above the thermoregulatory/homeostatic "set point" of ~37 degrees Celsius or ~99 degrees Fahrenheit. The clinical significance of this drug effect in relation to exercise is that it allows an individual to sustain a higher power output at a fixed level of perceived exertion (i.e., power output increases at fixed levels of perceived effort when an individual is under the effect of amphetamine). Due to the fact that this is primarily a dopaminergic effect in the CNS and the effect of amphetamine on dopamine efflux is most pronounced shortly after administration of immediate-release formulations, the effect of amphetamine on power output and body temperature is likely to be most pronounced during the first hour after ingestion of an oral dosage form.
For further information on what I've mentioned above, I would suggest reading the references that cite the relevant statements in the following sections of this article:
* https://en.wikipedia.org/wiki/Amphetamine#Physical_performance <-- Very relevant to this thread
* https://en.wikipedia.org/wiki/Amphetamine#Contraindications
* https://en.wikipedia.org/wiki/Amphetamine#Physical <-- Very relevant to this thread
* https://en.wikipedia.org/wiki/Amphetamine#Overdose
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