Hi!
I am a decade-long opiate/opioid user, chemist by profession and am recently taking Carfentanyl recreationally. If you like,
you can ask me anything about it since there is sooo many misinformation around.
I have been reading about the substance for years, also here, on opiophile and many other pages on the net. Being one/the of the most closely watched opioids in the world that are commercially available, (For example even zoos having additional rules that they apply to their
usual controlled substances rules like only handling it with two people, having antidote at hand, etc..) it seemed almost impossible to get
some human first-hand experience in actually using the substance. (Yes, I also read the story of someone buying it in a mexican pharmacy..
haha!).
I am also very experienced with fentanyl and its various analogues, from an academic view to synthesis to personal usage. Since I have taken about every opioid in the world that could be prescribed for my condition or to feed my habit, I have a very broad view in the field of fentanyls, also since I have chosen them years ago to become my way to go as an opiophile person since it has so many advantages. (Cheap, good painkiller, not making me too tired (stimulating me!), easy to have a lifelong supply if you can control their usage a little, not being organotoxic at all, etc..). The only thing that limits the mother compound´s (fentanyl) recreational value a bit is its lack of euphoria, or at least little.
So, to be honest I never thought that one day I actually will hold some carfentanyl in my hands, It is very,very, controlled, very rare (DEA quota for 2015 was 19g, so proliferation is almost unthinkable of) and its synthesis compared to fentanyl is much more demanding, but not impossible.. the precursors are mostly unwatched.
As some might have noticed, carfentanyl has actually turned up lately in some heroin batches, presumably imported from china as one 1kg! seizure from canadian police showed.
So, about a month ago I held 25mg of the substance in my hands. It is claimed to be pure, which I back up since it is totally crystalline and under the microscope the crystals look very clean, uniform and almost like table salt (but off course no cubic crystalline arrangement).
I didn´t do any further purity checks since I don´t have access to any analytical gear at the moment, but as I said I have a profession in the field, and I know when I have a pure substance, especially when its crystalline.
So, lets talk a little about carfentanyls properties.
First, it is an anilopiperidine derivate, with a 4-carbxcylic acid methylester modification on the fentanyl molecule. This changes its ANALGETICAL
potency 100-fold to the mother compund, fentanyl. Why I put analgetical in capitals? well, this is about recreational use. More on this later.
Carfentanyl has a Ki value for the mu-opioid receptor of 0.024 which is very high, but also some decent kappa receptor binding affinity.(Binding DB)
What can be pointed out here is that its therapeutic index is also, very high (about 10.000, fentanyl has 700) which is the quotient of minimum effective dose (50% of test subjects) and the lethal dose (also 50% of subjects) with respiration failure/depression being the most prominent toxic effect. So it is actually quite safe !!
Carfentanyl is stronger hypnosedative under analgesic equivalent doses as fentanyl. The threshold dose of carfentanyl in humans, visible when the first effects such as analgesia and sedation occur is in the range of about 1-2 micrograms, an effective dose can be 8-15 micrograms and higher doses are highly sedating and sleep inducing. At doses ranging from 50-100 micrograms it comes to loss of consciousness.
(Human with no opioid dependence. This claim is from german Wikipedia and I back this up highly from my experience.. besides the doses of course since I have tolerance).
So, what about Carfentanyl in my system?
Ok, I weighed 10mg of the substance, dissolved it in water/IPA mixture and dosed 100µg on a sheet of aluminium foil. I went by the claim that it is 100times stronger than fentanyl so that would be an equivalent of 10mg of fentanyl. A good dose for me. The dose was almost invisible on the foil after the solvent evaporated. I am aware of thermal decomposition when smoking, but if anything it would lessen the probability of overdose AND I don´t do IV usually, so this was the best way to compare before/after quick.
Well, I only felt a tiny bit of it, almost subtle. So up the dose one order of magnitude. At 1000µg I really felt the opiate effect, I would say that I got almost to the point which 10mg of fentanyl do to me.
So, for recreational use I would say that the potency is more like 10-15 times of fentanyl. Some days later I had a long planned surgery and had a needle in my arm anyways. So I put 1mg of carfentanyl in some saline and used IV. It gave my a like 0-20 seconds delayed feeling of comfort and warmth, so good and intense I didn´t have of any opiate for years. Very, very pleasant and off course very, very strong. The effects also lasted very very long. Longer than those of fentanyl. I somewhere read that it is 3 times slower metabolized (plasma half life of around 12h) than fentanyl which I back up by my experience. Some minutes later I felt asleep for like an hour, so yes, it is very sedating. I also felt euphoria, something I usually don´t get so much by plain fentanyl.
As you see, my main point why I write this is to say that it is not 100times stronger than fentanyl (for rec use). I´d say 10-15 times stronger.
But when you see where those claims come from, papers where the most common way of determining the potency is by the so called tail-flick test. Mice/rats are put on a hot plate (50°C) and it is measured how often they lick their tails or try to lift it from the plate in order too cool it.
The more potent the analgesic, the less they fell the heat, the less they flick the tail. So this is clearly an analgesic potency test.
When trying around while in hospital I also started at 10µg IV and I felt only subtle psychoactive effects, BUT I noticed my surgical pain vanish quite quick after using. So much for that.
Bottomline:
It replaced my choice of #1 opiate for me, which was fentanyl
It is cheaper, stronger, longer lasting, has higher safety margin(!!!),and induces euphoria. The comedown is easy and I din´t notice a higher tolerance buildup than straight fentanyl after 100mgs of usage so far. (they lasted about 25 days for me and that was heavy use). So if you take it on not too hard maybe 10g will last you a whole decade, probably more.
This stuff is getting very hard bashing from the media lately with very exaggerated claims because of the high overdose rate that occured in Ohio.
Most of the time when fentanyl-laced heroin does cause many overdoses it is because of bad mixing. I see this as a problem since this carfentanyl HCl´s occurence is very granular and not fine at all. But if you have the pure substance, you know what you are doing and with basic lab techniques it is very, very handleable. (talking of personal use!)
If you have any questions regarding first-hand experience by someone who most of the time knows what he´s doing, ask me anything!
