Albion
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MDPV
Updated from here.
~Sprout
Methylenedioxypyrovalerone (MDPV) is a psychoactive drug with stimulant properties which acts as a norepinephrine-dopamine reuptake inhibitor (NDRI). First developed in 1969, it remained an obscure stimulant until around 2004 when it was reportedly sold as a designer drug. It is also known as Cloud 9, MDPK, MTV, Magic, Maddie, Black Rob, Super Coke, PV and Peeve.
Methylenedioxypyrovalerone has no record of FDA approved medical use. Reportedly, it has four times the potency of methylphenidate (Ritalin, Concerta), although its pharmacology has only recently been studied in detail. MDPV is the 3,4-methylenedioxy ring-substituted analog of the compound pyrovalerone, developed in the 1960s, which has been used for the treatment of chronic fatigue and as an anorectic, but caused problems of abuse and dependence. However, despite its structural similarity, the effects of MDPV bear little resemblance to other methylenedioxyphenylalkylamine derivatives such as 3,4-methylenedioxy-N-methylamphetamine (MDMA), instead producing primarily stimulant effects with only mild entactogenic qualities.
The primary psychological effects have a duration of roughly 3 to 4 hours, with after effects such as tachycardia, hypertension, and mild stimulation lasting from 6 to 8 hours. High doses have been observed to cause intense, prolonged panic attacks in stimulant-intolerant users, and there are anecdotal reports of psychosis from sleep withdrawal and addiction at higher doses or more frequent dosing intervals. MDPV has been distinguished by some for its powers as an aphrodisiac. It has also been repeatedly noted for inducing strong cravings to re-administer. Users have reported a compulsive desire to continuously re-dose, even following onset of the unpleasant side effects induced by prolonged use and higher doses.
Extended binges on MDPV have also been reported to produce severe comedown syndrome similar to that of methamphetamine, characterized by depression, lethargy, headache, anxiety, postural hypotension (lightheadedness and weakness of the muscles), and in some cases severely bloodshot eyes, which usually subside within 4 to 8 hours. MDPV may also cause temporary bruxism or grinding of the teeth. Side effects are highly dose-dependent. No fatalities have so far been reported without the combination of other substances except for suicide.
Reported modalities of intake include oral consumption, insufflation, smoking, rectal and intravenous use. It is supposedly active at 3–5 mg, with typical doses ranging between 5–20 mg. MDPV loses potency when it is put into solution.
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