TheBlackPirate
Bluelighter
- Joined
- Dec 16, 2015
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The Wikipedia article on MAOIs was recently updated and now says dietary restrictions aren't necesary with the reversible MAO-A kind.
Reversible MAOIs are safer in comparison with irreversible MAOIs. The recommendation dietary restrictions aren't necessary with reversible MAO-A ihibitors goes against the traditional knowledge I had. I did look at the available abstract of the study given as evidence in the Wikipedia article. The abstract doesn't explain how they reached the conclusion, the doses involved, or if the results were obtained from human subjects.
I looked at the Wikipedia entry on Harmine (a constituent of Syrian Rue). The article says, while less risky than other MAOIs, dietary precautions are an advisable measure.
https://en.wikipedia.org/w/index.php?title=Monoamine_oxidase_inhibitorWikipedia (Monoamine oxidase inhibitor) said:Patients taking MAOIs generally need to change their diets to limit or avoid foods and beverages containing tyramine. If large amounts of tyramine are consumed, they may suffer hypertensive crisis, which can be fatal.[3] Examples of foods and beverages with potentially high levels of tyramine include liver and fermented substances, such as alcoholic beverages and aged cheeses.[25] (See a List of foods containing tyramine).
Tyramine leads to hypertensive crisis by increasing the release of norepinephrine (NE), which causes blood vessels to constrict (through binding to alpha-1 adrenergic receptors).[26] Ordinarily, MAO-A would destroy the excess NE. When MAO-A is inhibited, though, NE levels get too high, leading to dangerous increases in blood pressure.
Of note, no dietary modifications are needed when taking a reversible inhibitor of MAO-A (i.e., moclobemide) or low doses of selective MAO-B inhibitors (e.g., selegiline 6 mg/24 hours transdermal patch).[26][27][28]
Reversible MAOIs are safer in comparison with irreversible MAOIs. The recommendation dietary restrictions aren't necessary with reversible MAO-A ihibitors goes against the traditional knowledge I had. I did look at the available abstract of the study given as evidence in the Wikipedia article. The abstract doesn't explain how they reached the conclusion, the doses involved, or if the results were obtained from human subjects.
I looked at the Wikipedia entry on Harmine (a constituent of Syrian Rue). The article says, while less risky than other MAOIs, dietary precautions are an advisable measure.
https://en.wikipedia.org/wiki/HarmineWikipedia (Harmine) said:, and plants containing significant amounts of harmine and other harmala alkaloids are generally not considered safe treatments for depression within the medical community. This bias however is primarily built on previous decades of experience with pharmaceutical non-specific MAOIs that block both MAO-A and MAO-B.[14] Inhibiting MAO-A or MAO-B (in high enough doses) while consuming foods rich in tyramine, e.g. cheese, can cause tyramine, ordinarily metabolized by these enzymes, to accumulate to dangerous levels. This can cause a potentially fatal hypertensive crisis. Because harmine reversibly and selectively inhibits MAO-A and does not degrade MAO-B, MAO-B remains free to metabolize tyramine in the digestive tract. Consequently, the harmala alkaloids (including harmine) are unlikely to elicit tyramine-mediated hypertensive crisis, and a special diet does not need to be so strictly adhered to. Nonetheless, due to the reduction of the levels of tyramine degrading compounds in the gut, it is still not advisable to eat excessively large amounts of tyramine-rich food products.[15] The reversibility and MAO-A selectivity of harmala alkaloids do not, however, prevent potentially fatal interactions with common medications such as antihistamines, most antidepressants, many stimulants, common migraine medications, some herbs, decongestants, expectorants, and common cough and cold medications.
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