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Opioids Let's talk TRAMADOL!

Perhaps the SNRI action helped the migraine? Not so sure how effective for an acute attack it would be but maybe.
 
I'll post a response tonight when I get home and settled in. Thank you for the detailed explanation.
 
Thanks phil i want it to be a rapid taper hes offered to up the strength i think hes worried i go off it and im back to abusing oxycodone and targin hes known me for 2 yrs so its a high possibility def going to go to a lower dose in a few days thanks sd o mych fir ur advice
 
You could be right i think my dr mumbled something about it causing migraines. keeps saying iĺl be using needles next prob why he wants me to stay on subs feel depressed on it but i guess oxy used to make me feel really good and happy/high productive and pain free now i feel like a zombie ĺol .
 
You're very welcome Leelee, I hope you find relief soon.

I'm surprised you're feeling depressed on the buprenorphine, it has amazing antidepressant properties. In fact, if I was a doctor I'd prescribe it in low doses as an anti-depressant (like 0.5mg/day for depression or even anxiety).

Anyways, let us know whenever you need anything, the Bluelight population is amazing in every way, especially when it comes to sympathetic support.

Edit: Don't hesitate to start a new thread, probably in The Dark Side, to get more support. You'll be surprised how many people here are willing to help out and share their wisdom. Don't hesitate to PM me too if you need to ask something specific.
 
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Thank you for your very detailed response. My apologies for the tardy response, but I was in the midst of a nasty alcohol addiction and chaos ensued during the course of recovery. I agree with your points and acknowledge that drug defects occur in every drug company regardless of size or geographic location. I disagree on your contention that the Oxycodone ER and Oxycontin tablets were exactly the same due to first hand experience. The OC 80 was a very small tablet and every junky (myself included) sought and loved them for the euphoric high they produced whether you crushed, ate, or snorted it. The Oxycodone ER was a long fat horse pill that didn't produce the same high (or even close for that matter) as the OC 80. As a matter of fact, I had a blister sheet of them which had 15 or 20 tablets and the local heroin / oc junkies wouldn't touch them. One of the junkies told me they have different binders and don't release the same thereby not producing the same high. I snorted a whole 80 MG Oxycodone ER and subsequently took 2 more over the course of 2 hours because the first one I snorted produced such a shit result I just assumed I had gotten ripped off. Later on, I indeed had an intense opiate high but not enjoyable in any way like the OC 80's were.

If you're saying that Oxycodone ER was never marketed as OC generic and the pharmacy fleeced me, then I could accept that. If you're saying the horse pill was the same as the tiny OC, you quite obviously are not and never have been a drug user. I'm very interested to read your response on that point. However, with your extensive knowledge of the pharmaceutical industry, would you have any idea as to why different manufacturer's of Tramadol (or any pharmaceutical drug for that matter) would produce a different effect in the patient? I'm sure a geared out lab could find the difference, but I do not have a proper education much less a geared out lab :)

In my pursuit to answer this question on my own, I explained my situation to the doctor who then agreed to write "BRAND ONLY" on the prescription. I could hardly contain my excitement on the way to the pharmacy. I happily waited for my prescription to be filled and subsequently took 2 of the 50MG ULTRAM tablets. 1 hour after ingestion, I failed to achieve the feeling I was looking for. I was edgy, panicky, and aggressive in emotion. In conclusion, even the brand name Ultram as currently manufactured failed to replicate my original high. Very disappointing indeed.

If you search on google for tramadol generics not working, you'll see this is an issue that is not just happening to me. I'll entertain any plausible reason as to why this could be occurring. Could inactive ingredients change the way a drug interacts with the body? Something is amiss and I would love to know the reason why. Also, one of the nicest things about Tramadol (when the generic worked) was the subtle opiate itch that would ensue about 1-2 hours after ingestion. Along with the fantastic mood and elevated energy, the itching was quite welcome. Teva and Caraco made me itch considerably, all of the others did not as if there was no opiate effect.

I had a funny similar experience with Valium years and years ago. I was periodically getting Valium scripts from my Doc in my early 20's and I thought I'd see if the brand name was any better, so I ponied up the extra $$ and gave it a try. I can't tell you the why or the how, but I can tell you that the name brand Valium was not as effective as the generic. It took longer to kick in, it was weaker once it kicked in, and altogether simply wasn't the same. Could it have been different fillers decreasing the bio availability in my gut? Who knows, but there was most certainly a difference. I'll say this, The brand name Ultram I currently have is very similar in effect to the Sun Pharma, Amneal, and Zydus generic Tramadol. Teva was nothing like any other Tramadol. It was very sedating and made me look doped up. No other generic or name brand Tramadol has done such a thing. I believe the source of the problem is simple greed. Tramadol is big money and the manufacturers have found a cheaper way to produce the product thereby affecting the end product. Anyhow, my post is getting a little long in the tooth so I'll shut myself up and look forward to a possible response.
 
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RE: the brand.
As most peoplein the UK do, my prescription just says "Tramadol" so the pharmacy just give me whatever brand they have in stock.
I agree that the there can be quite a big difference between brands.
Apparently, according to UK quality law, tablets must be "within 20% of stated doseage".
So in one brand 100mg may only be 80mg, while another could be 120mg.

The brand Accord is the strongest IMO/IME. It feels significantly stronger than all other brands. I'm always excited when I get them.
 
Just so you know, I've had every generic tramadol there is, I could never tell a difference between them because 99.9 percent of the time it always just did nothing.
 
Tramadol worked for me, and I used it a handful of times to battle heroin withdrawal, and it's great for that.

However, I tried 300+ mg a few times and EVERY time I would end up laying in bed feeling like vertigo. I guess that is serotonin syndrome? Almost threw up and I have a high opiate tolerance.
 
roxi2873 said:
Just so you know, I've had every generic tramadol there is, I could never tell a difference between them because 99.9 percent of the time it always just did nothing.
Click to expand...

Do you get high off of codeine ? If not it could be due to a gene mutation (CYP2D6)
 
I used & had withdrawal from tramadol every month from the age of 19 to 30.

It was one of my favorite opioids next to heroin.

Even when I had no tolerance, I still needed to take the daily max dose to really feel it.
I find tramadol better than buprenorphine honestly.

When I was using tramadol or heroin, I could listen to my music for hours & hours & totally be entranced in it.
I would even get up & exercise or go for super long walks. I just felt so wonderful, peaceful.
But they were not my prescription & eventually I lost them. Been on bupe for the last 5 years.
Buprenorphine does not offer me the same peacefulness or interest in music or exercise unfortunately.
Although it is useful for withdrawal & mild depression relief.

Bupe + tramadol is a very nice combo as well.
 
DeathIndustrial88 said:
I used & had withdrawal from tramadol every month from the age of 19 to 30.

It was one of my favorite opioids next to heroin.

Even when I had no tolerance, I still needed to take the daily max dose to really feel it.
I find tramadol better than buprenorphine honestly.

When I was using tramadol or heroin, I could listen to my music for hours & hours & totally be entranced in it.
I would even get up & exercise or go for super long walks. I just felt so wonderful, peaceful.
But they were not my prescription & eventually I lost them. Been on bupe for the last 5 years.
Buprenorphine does not offer me the same peacefulness or interest in music or exercise unfortunately.
Although it is useful for withdrawal & mild depression relief.

Bupe + tramadol is a very nice combo as well.
Click to expand...
What dose did you use with no tolerance?
 
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