Sorry, mate.
But I'm bonked, and zonked and fairly unzipped
rattled and addled and barely unripped.
But I am not yet so sloughed and uncorked,
that I couldn't bet to stay glued and ungorked.
In other words, I'm high but not so high I think I'd muck up this whole post. But here goes,
And what about ketamine + SNRI?Isnt it very similar to DXM?
Sadly, I am far too ignorant of the underlying pharmacodynamic and pharmacokinetic properties that are the result of NMDAR antagonists combined with SNRIs.
I'm no erudite pharmacologist. But I am an intrepid (some might argue foolhardy) experimentalist. And nothing is quite as interesting to experiment with as are drug combinations, from my perspective as a soi-disant psychonaut.
And so, while having no useful analytical knowledge of these combinations, I do have quite a bit of potentially useful empirical knowledge of them.
In regards to only SNRIs administered concomitantly with only ketamine and/or ketamine cognates, I have assayed the following:
1.) ketamine + venlafaxine + duloxetine;
2.) ketamine + esketamine + chlorphenamine + venlafaxine + mirtazepine + sibutramine;
3.) n-ethylnorketamine + esketamine + venlafaxine;
4.) ketamine + 2-MeO-2-deschloroketamine (methoxyketamine) + chlorphenamine + mirtazepine + duloxetine;
5.) methoxetamine (
does that even count as a relative of ketamine?) + n-ethylnorketamine + sibutramine + brompheniramine (
does that count as an SNRI? Oy vey!) + venlafaxine;
According to the descriptions I had written down in my drug diary and the recordings I have collected (for when written documentation of the experience becomes impractical or complicated), compared to ketamine administered in isolation none of these combinations produced an effect remarkably more similar to those of either DXM or any other morphinan derivative I have ever experienced.
However, as I presume we all are fully aware, most dissociatives feel noticeably similar to each other in some inexplicable, amorphous way—that
je ne sais qoui essence of dissociative anaesthesia, I call it. And in much the same way as amphetamine's or meth's or 4-MAR's effects greatly overlap with those of other psychostimulants, one should be cognizant of the fact that, when comparing two or more drugs of basically the exact same pharmacological nature, one can easily delude themselves into thinking the one is the other and the other is the one—PCP and TCP are practically the same thing with different potency, for example.
Thus, there exists a considerable potential here to confuse oneself and create similarities or dissimilarities between drugs that simply do not exist.
And in conclusion, my assessments should be taken for what they truly are: highly subjective and personalised, rather than scientific and definitive.
(That is to say, your mileage may vary to a considerable degree, and your own self-assay may lead you to disparate conclusions.)
Although I must say that I consider DXM experience pretty unique and it appears it's actually due to serotonergic effects, I remember one trip on DXM with a total dose of 375mg split in two doses (150mg + 225mg 90 minutes later), it was one of the best trips ever for me, for however long I was sitting on a chair with my eyes closed listening to trance via headphones and I was seeing this giant dark blue sphere and small particles orbiting around it until they were sucked in right in the middle of the sphere. Actually, the dark blue sphere actually felt like it was a point in my head. 3-MeO-PCP is a very unique compound too and I guess it's also due to additional serotonergic effects, the psychedelic headspace is quite similar for both compounds.