Chamomile, Skullcap, cannabis with self control and knowledge of what your smoking, and most herbals.
Really though any drug..... Cocaine, Heroin, Meth, and even PCP all have their values. While they are harmful to the body sometimes the benefit outweighs the negative. Say someone is narcoleptic and requires meth to stay awake possibly even cocaine could be an alternative as something to use during narcoleptic drowsy moments while getting out of the body quite quickly vs meth that could keep you up for 3 days. It is really all about the dose and the reason it is used for. If it numbs you from feeling that are to much is not beneficial. If it allows you to feel more and work through those issues without getting overwhelmed then it can be beneficial, but only if used in doses and amounts that don't lead to damage from possible toxicity.
This seems like a thread so people can recommend you drugs, which is against the rules on this board. Don't be sad if this topic gets closed.
Edit: I will add I smoke cannabis for muscle spacisity and use opiates to manage some pain that would be considered moderate on the verge of severe due to the chronic state of pain that just gets worse and worse the longer it goes on that I am finally getting into physical therapy for after 5 years of hell including 2 years of homelessness all over guess what.... Drugs! Most of the damage in my life that has been done by drugs is the reputation I have to deal with being one that uses drugs yet with minimal support even with the attitude most the times that the idea that it is medication is entertained to get me on with my life, but it's ok for anyone who just wants to put me down for struggling getting by with minimal amounts of medication I should be given enough to have spare left over and not feel constantly on edge of pain and even withdrawals at time from medication prescribed to treat me as if I am just a manipulative drug user when I do exactly what I have been taught to do growing up, excluding the abusive lessons I was taught to sit by and watch as I get neglected and even used afraid to say a word or express any emotion with fear of pain after over excessive spankings that weren't the worst of spankings, but were only out of rage and in response to me having "temper tantrums," expressing my emotion, or protesting my rights that is the foundation and backbone the country that is known as the land of freedom where freedom isn't free.
As far as usage when my medication is stable I am extremely functional more so than without anything, I am able to eat well, I sleep properly, my aspergers like symptoms become much less severe allowing me to interact with the people around me and clearly express my thoughts that I obviously have issues with from my mixed up posts, and really I find myself happier and more alive than again even being sober where I ended up being an antisocial mess that subconsciously was slightly suicidal definitely morbid. I do know at some point my daily use will stop, but right now it is the only thing keeping my life together and not just because I am dependent on the medication and will go through even more hell if stopped inappropriately. Learn your medications, but more importantly learn your own body and what medications it may need. Drugs aren't just tools of enhancement and pleasure, but can be a grounding and balancing tool to help one find stability in a chaotic time of life.