notgenuine
Bluelighter
- Joined
- Apr 20, 2013
- Messages
- 35
What are the indirect options how Peevee could damage your brain?
N&PD Moderators: Skorpio | thegreenhand
Methylone and mephedrone have been cleared of causing neurotoxicity, but there appears to be less information regarding MDPV neurotoxicity at the moment. According to one study, MDPV like cocaine, is a DA/NE reuptake inhibitor--it prefers catecholamines--with little to no affinity for 5-HT, and it appears to be about 10x stronger by weight than cocaine at eliciting classic responses of cocaine in rodents. Based on this information, it may be safe to say that, while MDPV induced neurotoxicity has not been ruled out, there is no particular reason to suggest that recreational doses of MDPV, used occasionally, are neurotoxic.
MDMA at 3 doses of 2.5mg/kg and 7.5mg/kg produced "persistent depletion of striatal and cortical 5-HT" that methylone and mephedrone did not.