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N&PD Moderators: Skorpio | thegreenhand
MAOI and Fumarate
- Thread starter Brendles
- Start date
They are both just salts of DMT, in the end they bind just as freebase dmt would. Chemicals are salted to increased bioavailabity, or sometimes they are salted upon synthesis/extraction. The different salts will not be affected any differently by monoamine oxidase.
sekio
Bluelight Crew
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in the body the dmt does not stay bound to the salt. upon oral ingestion it will be converted to the hcl salt because of the presence of hydrochloric acid secreted into the stomach
the two salts are different only in solubility, melting points, etc. and differ only slightly in potency. otherwise the effects are identical and mao works on them both exactly the same
the two salts are different only in solubility, melting points, etc. and differ only slightly in potency. otherwise the effects are identical and mao works on them both exactly the same
Just means that someone took the active compound and made it a salt. For example, DMT can be salted to make DMT hydrochloride.
Limpet_Chicken
Bluelighter
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Albeit with great difficulty in the preparation of a solid, crystalline HCl salt in the case of DMT, Shulgin notably said he had great difficulty and could obtain the product only as a resinous compound.
Fumarate tends to get used in pharmaceutical research w/DMT (and other things) as its both fairly nontoxic as a counterion for preparing salts of things in the case of which HCl salts are not generally amenable for animal/human investigations for solubility, toxicity reasons etc. and for crystallising things of dubious solubility as hydrochlorides.
As said, once taken orally (of course not, without MAOI, of much use at all in the case of DMT) once the compound reaches stomach acid then the HCl salt is formed in solution in situ, and in any case when given intravenously or other parenteral route, then (and once they reach the brain) dissociation of the counterion from the freebase drug occurs in any case.
Fumarate tends to get used in pharmaceutical research w/DMT (and other things) as its both fairly nontoxic as a counterion for preparing salts of things in the case of which HCl salts are not generally amenable for animal/human investigations for solubility, toxicity reasons etc. and for crystallising things of dubious solubility as hydrochlorides.
As said, once taken orally (of course not, without MAOI, of much use at all in the case of DMT) once the compound reaches stomach acid then the HCl salt is formed in solution in situ, and in any case when given intravenously or other parenteral route, then (and once they reach the brain) dissociation of the counterion from the freebase drug occurs in any case.
The point is however, if what he would be purchasing is truely DMT HCL its more economical to purchase the HCL rather than the fumerate. The salt has already been prepared.
