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Mental Health Schizophrenia

Psilocinman

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Jan 21, 2014
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Hi all, I was reading about schizophrenia(didn't get too in depth into) and I read that the reason that a person is schizophrenic is because they have excess phenethylamine/dopamine built up in their brain and that it overwhelms the TAAR1 and deactivates it. So wouldn't it also stand to say schizophrenics have an MAO b deficiency? And wouldn't it be possible for a certain drug to go in and break down excess phenethylamine/dopamine or something to raise their MAO b to break down excess phenethylamine/dopamine and reactivate the TAAR1?
 
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Too much trace amine activation is hypothesized primarily for the paranoid subtype. MAOI stops the neurotransmitters from being broken down. MAOI B agents increase levels of trace amines. Do you mean MAO?
 
From my knowledge I don't see why it wouldn't be possible. I don't know the mechanism by which one becomes especially sensitive to these chemicals. I do know that MOAIs aren't totally contraindicated in schizophrenia though. Sometimes they're used for psychotic disorders. I would bet that an anti-psychotic for the positive symptoms plus another agent for the negative symptoms (such as sometimes a MAOI) would be best, but I'm not a doctor. I think that increasing MAO would just make one really depressed, even suicidal. It's an interesting thought, though.
 
Anosognosia

Just laying down a list from this website on the symptoms I've experienced in bold. Also, note the disclaimer at the end.


Examples of Physical Symptoms----

--A blank, vacant facial expression. An inability to smile or express emotion through the face is so characteristic of the disease that it was given the name of affective flattening or a blunt affect. (Anosognosia maybe?)
--Overly acute senses- lights are too bright, sounds are too loud.
--Staring, while in deep thought, with infrequent blinking.

--Clumsy, inexact motor skills
--Sleep disturbances- insomnia or excessive sleeping
--Involuntary movements of the tongue or mouth (facial dyskinesias). Grimacing at the corners of the mouth with the facial muscles, or odd movements with the tongue.
--Parkinsonian type symptoms- rigidity, tremor, jerking arm movements, or involuntary movements of the limbs
--An awkward gait (how you walk)
--Eye movements- difficulty focusing on slow moving objects
--Unusual gestures or postures
--Movement is speeded up- i.e. constant pacing
--Movement is slowed down- staying in bed (in extreme cases, catatonia)


Examples of Feelings/Emotions----

--The inability to experience joy or pleasure from activities (called anhedonia)
--Sometimes feeling nothing at all
--Appearing desireless- seeking nothing, wanting nothing
--Feeling indifferent to important events
--Feeling detached from your own body (depersonalization)
--Hypersensitivity to criticism, insults, or hurt feelings


Examples of Mood----

--Sudden irritability, anger, hostility, suspiciousness, resentment
--Depression- feeling discouraged and hopeless about the future
--Low motivation, energy, and little or no enthusiasm
--Suicidal thoughts or suicidal ideation
--Rapidly changing mood- from happy to sad to angry for no apparent reason (called labile mood)
--Severe Anxiety


Changes in Behavior associated with schizophrenia ----

--Dropping out of activities and life in general
--Inability to form or keep relationships
--Social isolation- few close friends if any. Little interaction outside of immediate family.
--Increased withdrawal, spending most of the days alone.
--Becoming lost in thoughts and not wanting to be disturbed with human contact
--Neglect in self-care- i.e. hygiene, clothing, or appearance
--Replaying or rehearsing conversations out loud- i.e. talking to yourself (very common sign)
--Finding it difficult to deal with stressful situations

--Inability to cope with minor problems
--Lack of goal-directed behavior. Not being able to engage in purposeful activity
--Functional impairment in interpersonal relationships, work, education, or self-care
--Deterioration of academic or job-related performance
--Inappropriate responses- laughing or smiling when talking of a sad event, making irrational statements.
--Catatonia- staying in the same rigid position for hours, as if in a daze.
--Intense and excessive preoccupation with religion or spirituality
--Drug or alcohol abuse
--Smoke or have the desire to want to smoke (70-90% do smoke) - note: this is a very normal behavior for people who do not have schizophrenia also!
--Frequent moves, trips, or walks that lead nowhere


Examples of Cognitive Problems Associated with Schizophrenia ----

--Ruminating thoughts- these are the same thoughts that go around and round your head but get you nowhere. Often about past disappointments, missed opportunities, failed relationships.
--Making up new words (neologisms)
--Becoming incoherent or stringing unrelated words together (word salad)
--Frequent loose association of thoughts or speech- when one thought does not logically relate to the next. For example, "I need to go to the store to buy some band-aids. I read an article about how expensive AIDS drugs are. People take too many street drugs. The streets should be clean from the rain today, etc" The need to go to the store to buy band-aids is forgotten.
--Directionless- lack goals, or the ability to set and achieve goals


--Lack of insight (called anosognosia). Those who are developing schizophrenia are unaware that they are becoming sick. The part of their brain that should recognize that something is wrong is damaged by the disease.
--Racing thoughts
--In conversation you tend to say very little (called poverty of speech or alogia)
--Suddenly halting speech in the middle of a sentence (thought blocking)


--Trouble with social cues- i.e. not being able to interpret body language, eye contact, voice tone, and gestures appropriately. --Often not responding appropriately and thus coming off as cold, distant, or detached.
--Difficulty expressing thoughts verbally. Or not having much to say about anything.
--Speaking in an abstract or tangential way. Odd use of words or language structure
--Difficulty focusing attention and engaging in goal directed behavior
--Poor concentration/ memory. Forgetfulness
--Nonsensical logic

--Difficulty understanding simple things
--Thoughts, behavior, and actions are not integrated
--Obsessive compulsive tendencies- with thoughts or actions
--Thought insertion/ withdrawal- thoughts are put it or taken away without a conscious effort
--Conversations that seem deep, but are not logical or coherent


Examples of Delusions----

The most common type of delusion or false beliefs are paranoid delusions. These are persecutory in nature and take many forms:

--Overpowering, intense feeling that people are talking about you, looking at you
--Overpowering, intense feeling you are being watched, followed, and spied on (tracking devices, implants, hidden cameras)
--Thinking that someone is trying to poison your food
--Thinking people are working together to harass you
--Thinking that something is controlling you- i.e. an electronic implant
--Thinking that people can read your mind/ or control your thoughts
--Thinking that your thoughts are being broadcast over the radio or tv
--Delusions of reference- thinking that random events convey a special meaning to you. An example is that a newspaper headline or a license plate has a hidden meaning for you to figure out. That they are signs trying to tell you something.
--Religious delusions- that you are Jesus, God, a prophet, or the antichrist.
--Delusions of grandeur- the belief that you have an important mission, special purpose, or are an unrecognized genius, or famous person.

--Delusions that someone, often a famous person, is in love with you when in reality they aren't. Also called erotomania or de Clerembault syndrome.

Examples of Hallucinations----

--Hallucinations are as real as any other experience to the person with schizophrenia. As many as 70% hear voices, while a lesser number have visual hallucinations.
--Auditory hallucinations can be either inside the person's head or externally. When external, they sound as real as an actual voice. Sometimes they come from no apparent source, other times they come from real people who don't actually say anything, other times a person will hallucinate sounds.
--When people hear voices inside their heads, it is as if their inner thoughts are no longer alone. The new voices can talk to each other, talk to themselves, or comment on the person's actions. The majority of the time the voices are negative.
--Visual hallucinations operate on a spectrum. They start with the overacuteness of the senses, then in the middle are illusions, and on the far end are actual hallucinations.




Disclaimer: The following symptoms overlap with many other diseases such as bipolar disorder, major depression, the various kinds of personality disorders (specifically paranoid and schizotypal personality disorders), and other problems such as brain tumors and temporal lobe epilepsy. There is no "typical" case of schizophrenia. Everyone has different symptoms. Seek the opinion of your doctor always.

Moreover, it is always important to keep the big picture in mind. Having just a few of these symptoms does not necessarily mean that a person has schizophrenia, or any other sort of psychiatric disorder. Almost all of the signs below can be present to a "normal" degree in people; it is when someone displays them to a significant degree that they can become psychiatric symptoms. Think if all of these behaviors as being on a continuum, in which the middle 99% of people displaying varying degrees of the behavior, but are still within the "normal" range. The 1% of people on the outer edges have the behaviors in extreme proportion, and/or a significant proportion of the time, and that is when they can become debilitating.
 
We simply can't diagnose you over the internet, not to mention that we're not doctors. If you're having issues, and it certainly sounds like you are, please see a doctor promptly. How else can I be of service?
 
In most cases a doctor must rule out various other forms of mental illness as well as take into account other factors before a proper diagnosis is made. I suffer from this condition and if you want to PM me I do not mind talking a bit more on this subject.
 
We simply can't diagnose you over the internet, not to mention that we're not doctors. If you're having issues, and it certainly sounds like you are, please see a doctor promptly. How else can I be of service?

If you're directing that at me, I wasn't asking anyone to give me a diagnosis. Take the post as it is and no more.
 
I work with many people with schizophrenia and they get by just fine with fortnightly injections of Risperidone and others. The only time there are any serious problems is when people believe they are cured and stop receiving their meds.
 
Or experiencing serious problems with health? Im sure its hard to take injections for the rest of the life,sometimes its good to have some belief..its not like its cancer
 
Or experiencing serious problems with health? Im sure its hard to take injections for the rest of the life,sometimes its good to have some belief..its not like its cancer
Suicide due to schizophrenia tops cancer deaths worldwide. Mortality rate 4 times higher than general population. Suicide and cancer the biggest killers for schizophrenics.
 
I don't think there is any one cause for schizophrenia. Yes, maybe sometimes it is due to neurological causes, but this is probably often not the case. I think that there are often unconscious causes behind it much of the time such as a history of abuse, discrimination, or other forms of trauma. It's definitely more than simply a neurological illness. It's sort of a defense mechanism gone awry. The voices and visual hallucinations that schizophrenics hear are essentially figments of their unconscious being presented to them.
 
Jung thought that, about 100 years ago. It's generally accepted now that it is purely neurological. It's nice to think things happen for a reason but often they don't.
 
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