I know the thread is old, but throughout the past 9 months that I have been off and on the vivitrol shot I have had burning questions that I have not been able to find definitive answers for on the internet and abroad, so me being the curious cat I am, I used the scientific method to test my hypotheses. First question I had was can you feel the effects of suboxone while on the shot? And the answer is quite simple. After my last injection I was dirty for my shot and went into PWD, and had a nice case of PAWS to top it off. I was in agony. Bought a 8mg suboxone strip and used (IV), and it helped tremendously. Even got a nice buzz. So yes, you can feel at least IV suboxone while on the shot. At least I can. My second question was, exactly how long does it take for the shot to wear off? Well this one is tricky. I think it depends on a few factors. Obviously your individual metabolism and overall health is big, but also something that no one really mentions. Where the shot is administered, in my experience, is a HUGE factor in how long it has a hold on your receptors. In my outpatient program we have a nurse that administers the shot regularly to hundreds of people, and he will correctly give the shot in your ass cheek, as its supposed to be given. While I was in this program receiving the shot from this nurse, I could always use after I "missed" my shot, within 3-4 days. Equals out to about day 31-34. This past month I got the shot from a different source (kicked out of IOP for using) and the nurse gave me my shot in my lower back area, above my left ass cheek. It is now day 33, there is STILL a lump where I received my shot, and I cannot get any sort of euphoria. If I feel nothing by my pay day (5 more days), then I can conclude at least for myself, that an injection in the "wrong spot'" can add extra time onto the already agonizing 28 days. A few more notes, not really questions I've had, but answers for some people who may have these questions in their run with vivitrol. For the sake of science. There's is minimal buildup on your receptors from multiple months of shots. After my 5th shot I missed my appointment, and used 2 days after and experienced a satisfying rush. In my outpatient program I was forced to give urine samples twice a month randomly. On these UA's they give ng levels of drugs in your body, including the infamous naltrexone. On my last UA I read the levels (since I had been using I was curious) and noticed that I STILL had naltrexone in my system, but had also been using. The amount of naltrexone in my system was minimal, nowhere near the amount I was giving in earlier screens. The point is that I was definitely getting high, rush and all, while still technically on naltrexone. My theory is this; the shot (380mg) is supposed to administer itself intramuscularly throughout a "28" day period, which equals out to 15mg (give or take) a day. I think that it releases in stronger amounts in the earlier days, and after a certain threshold of time, the amount dwindles lower and lower. So instead of 15mg every day for 28 days, its more like 25-30 mg in the first two weeks, and gets less and less as the days go by until its nonexistent. The shot definitely does its job, the earliest I've been able to get any sort of high was on day 31. There's no reason to waste your hard earned monies. I've heard and read accounts of people using way too early into their shot and claiming they got high, which is bs. I'm telling you its a placebo, and don't get your hopes up by reading their accounts. I am a 6ft tall male weighing at 160 pounds, lean, in shape, with a faster than normal metabolism and still have to wait the entire length of time and then some to get high. Like I said, its day 33 as of today and I used this morning and felt maybe 5-10% of the high that should have put me on my ass. I said in the beginning. If your cravings are THAT bad, get your hands on a suboxone or two to give you the itch you've been craving, if you're early into your shot. On the bright side though, I have found that when you first experience any sort of high from opiates while on the tail end of vivitrol, as the days pass you will feel more and more of the high you seek. Example, if on day 35 you feel about 25% of the high, the next day will be 30%, day after 40%, etc. They SAY the half life is 5-10 days. I have hypothesized that its more like 10 days at the beginning, but dwindles down to five throughout the length of the shot. Because at the tail end the rate of excretion is exponential. I was UA'd on a Thursday and again the following Monday (I missed my shot the Thursday I was tested) and on that Monday the results showed that almost half of what was there was excreted in almost 3 days. Your body wants it out as much as you do, give it time. Do things to increase your metabolism. Eat healthier, take multivitamins, exercise. If you truly want to be clean and sober (as I did when I first started the program) the vivitrol shot is a godsend. Cravings won't be too bad because you truly don't want to use, and you have the failsafe of naltrexone blocking your receptors. For those not ready to quit, and forced Into getting the shot (as I also was this past month because of probation) its really not for you. PAWS is no joke. You ask, "how can someone really be that depressed and suicidal just because they can't get high?" and I felt the same way until I got the shot when I was still in active addiction. I felt like my life had been stolen from me. I was mad at the world, pissed off that someone could force me to get something that prevents me from getting high, when I'm an adult and can make my own decisions. But some girl at a desk can make me get it, or risk going to jail? I went through a day or two of anger, and then another day or two of basically sadness. Mindless using to no avail, just wishing i could get some sort of buzz, and wasting TONS of money. Like I said I didn't mean to post on an old thread, but since I'm at the end of my run with vivitrol, and do not plan on receiving another injection, I figured I'd post my experience to hopefully answer questions some lurker may have about the drug that is vivitrol. I hope your month is shorter than mine has been, and happy hunting.