In my experience, it is not a wise thing to do. While I am prescribed 80mg Propranolol XR (active for 12 hours) together with dexedrine, low therapeutic doses are not concidered unsafe, BUT i once took my normal morning dose after a nightly stim binge and when the propranolol started working it got very nasty, I felt the propranolol set in and my body started tingling starting at my feet moving up to whole body, panic set in and then it felt like my veins in my arms turned to stone, i was dizzy and desorientated, cold sweat started pouring out of me, I took cold showers that seemed to help a bit, but I was very lucky to get trough it and stupid not to call emergency services as it could have gone another way..
I had read those stupid reports of treating od patients with a very LOW dose of Propranolol, so was not aware of the risk and actually thought I was doing the right thing at the time..afaik nowadays they no longer get Propranolol but a benzo at the ER...
But strangely enough, I have combined stims before mostly (but not always) at night when xr had mostly lost its effect, my theory is that you perhaps with carefull dosing after most of the propranolol is out of your system have a better control and feel of whats happening a tight feeling in arms is an indicator not to proceed any further (a benzo might provide some relief), this is probably vasoconstriction increasing and/or rising blood preassure, propranolol is still active in your system and you are above safe dosage of your stimulant.
This is only my personal speculation not something to rely on as this might not happen to you and you might get no gentle warning.
Taking propranolol after or during a stim binge (or perhaps shortly before) is russian roulette as you cant really indicate how it will react and how much adrenergenic action there is it will oppose (I can go in to further detail later but have to look up some articles to be sure I explain correctly, but hope this will suffice) and thereby creating a sort of feedback loop and paradoxial effects like increased vasoconstriction and it will instead increase bloodpressure. This can be life threathening so immediately call emergency services.
I do NOT advise taking recreational doses of any stimulant within 12 hours of 80mg Propranolol (nor other dosages or the IR version) some of my experiences above regarding earlier experiences of use after taking Propranolol are for for beedback and ideas of others and to provide perhaps early warning signs for when mistakes are being made.
Always be very carefull and do not combine them, so if you are not taking them for blood pressure / heart conditions or other conditions where skipping a dose of propranolol is dangerous to your health..so be sure to know if this is the case first! do not take it on days when you induldge in stims or take only a low dose IR in the morning so you are free at night or at least wait 12 hours after intake and then take it slow!..moderate dosing doesn't seem to give problems then... And be carefull and only take next dose when you are sure to be fully sober again, after a nights sleep is my general rule now, as it really is especially unsafe taking Propranolol after recreational use in my experience as i didn't feel very stimulated but some stims have subtle residual stimulation and it might not be very obvious and that is the point.. Do not gamble, It gave a reaction I will never forget, be safe, do not combine!
I hope this is acurate enough I wrote it from memory but this is the jest of it, do not take propranolol while stimmed period!
