Mr.Scagnattie
Bluelighter
- Joined
- Feb 3, 2004
- Messages
- 12,850
Version 1
Loperamide is an opioid drug used against diarrhea resulting from gastroenteritis or inflammatory bowel disease. In most countries it is available generically and under brand names such as Lopex, Imodium, Dimor, Fortasec, Lopedium, Gastro-Stop and Pepto Diarrhea Control.
Loperamide is an opioid-receptor agonist and acts on the μ-opioid receptors in the myenteric plexus of the large intestine; by itself it does not affect the central nervous system. It works similarly to morphine, by decreasing the activity of the myenteric plexus, which in turn decreases the tone of the longitudinal and circular smooth muscles of the intestinal wall. This increases the amount of time substances stay in the intestine, allowing for more water to be absorbed out of the fecal matter. Loperamide also decreases colonic mass movements and suppresses the gastrocolic reflex.
Ability to cross the blood–brain barrier:
It is a misconception that loperamide does not cross the blood–brain barrier. Loperamide does cross this barrier, although it is immediately pumped back out into non–central nervous system (CNS) circulation by P-glycoprotein. While this mechanism effectively shields the CNS from exposure (and thus risk of CNS tolerance/dependence) to loperamide, many drugs are known to inhibit P-glycoprotein and may thus render the CNS vulnerable to opiate agonism by loperamide.
Concurrent administration of P-glycoprotein inhibitors such as quinidine and its other isomer quinine (although much higher doses must be used),PPIs likeomeprazole(Prilosec OTC) and even black pepper (piperine as the active ingredient) could potentially allow loperamide to cross the blood–brain barrier. It should however be noted that only quinidine with loperamide was found to produce respiratory depression, indicative of central opioid action.
Loperamide has been shown to cause a mild physical dependence during preclinical studies, specifically in mice, rats, and rhesus monkeys. Symptoms of mild opiate withdrawal have been observed following abrupt discontinuation of long-term therapy with loperamide.
Loperamide 2mg
Imodium (brand name loperamide)
In high doses, loperamide has been shown to alleviate withdrawal symptoms from opiate dependency. Dose varies based on tolerance, but many people report (at the correct dose for their individual tolerance), total removal of withdrawal symptoms.
*****Warning*****
More and more people, non-opiate tolerance individuals, who are attempting to take high doses of loperamide to get high, are overdosing and dying. We have had 2 just very recently.
Loperamide should NOT be taken in such high doses unless for the purposes of treating opiate withdrawal symptoms, by individuals with a history of opiate use, and a high tolerance.
The recreational properties of loperamide are almost non-existant. It is not known for its "high". So, attempting to take enough to cause euphoria is simply incredibly dangerous and lacking any possible reward. This is not a recreational substance.
Do not attempt to ingest high does of loperamide to achieve a high.
*****Warning*****
Loperamide
Loperamide is an opioid drug used against diarrhea resulting from gastroenteritis or inflammatory bowel disease. In most countries it is available generically and under brand names such as Lopex, Imodium, Dimor, Fortasec, Lopedium, Gastro-Stop and Pepto Diarrhea Control.
Loperamide is an opioid-receptor agonist and acts on the μ-opioid receptors in the myenteric plexus of the large intestine; by itself it does not affect the central nervous system. It works similarly to morphine, by decreasing the activity of the myenteric plexus, which in turn decreases the tone of the longitudinal and circular smooth muscles of the intestinal wall. This increases the amount of time substances stay in the intestine, allowing for more water to be absorbed out of the fecal matter. Loperamide also decreases colonic mass movements and suppresses the gastrocolic reflex.
Ability to cross the blood–brain barrier:
It is a misconception that loperamide does not cross the blood–brain barrier. Loperamide does cross this barrier, although it is immediately pumped back out into non–central nervous system (CNS) circulation by P-glycoprotein. While this mechanism effectively shields the CNS from exposure (and thus risk of CNS tolerance/dependence) to loperamide, many drugs are known to inhibit P-glycoprotein and may thus render the CNS vulnerable to opiate agonism by loperamide.
Concurrent administration of P-glycoprotein inhibitors such as quinidine and its other isomer quinine (although much higher doses must be used),PPIs likeomeprazole(Prilosec OTC) and even black pepper (piperine as the active ingredient) could potentially allow loperamide to cross the blood–brain barrier. It should however be noted that only quinidine with loperamide was found to produce respiratory depression, indicative of central opioid action.
Loperamide has been shown to cause a mild physical dependence during preclinical studies, specifically in mice, rats, and rhesus monkeys. Symptoms of mild opiate withdrawal have been observed following abrupt discontinuation of long-term therapy with loperamide.
Loperamide 2mg
Imodium (brand name loperamide)
Use in Opiate Withdrawal
In high doses, loperamide has been shown to alleviate withdrawal symptoms from opiate dependency. Dose varies based on tolerance, but many people report (at the correct dose for their individual tolerance), total removal of withdrawal symptoms.
*****Warning*****
More and more people, non-opiate tolerance individuals, who are attempting to take high doses of loperamide to get high, are overdosing and dying. We have had 2 just very recently.
Loperamide should NOT be taken in such high doses unless for the purposes of treating opiate withdrawal symptoms, by individuals with a history of opiate use, and a high tolerance.
The recreational properties of loperamide are almost non-existant. It is not known for its "high". So, attempting to take enough to cause euphoria is simply incredibly dangerous and lacking any possible reward. This is not a recreational substance.
Do not attempt to ingest high does of loperamide to achieve a high.
*****Warning*****
Last edited by a moderator:
