I know I'm bumping an old thread, but, I have some input. I was high as shit and had to get blood work done. I went OD when the nurse drew my blood. Idk why, maybe plasma levels? But I believe the more blood (or H water) in your circulatory system, the more you can tolerate. Therefore, the less water used, the less fluid being pumped around. I was surprised at how the little amount of blood drawn affected me so greatly. I have always been told the least water, the harder it hits you. I am a firm believer of this. This isn't a junkie myth, there is some biological/scientific basis for this claim. I am not a scientist or a biologist. So take my statement for what it's worth to you. I was fine, nodding out but in control, until he drew the blood. I could feel myself slipping and told him to stop several times. He didn't because he thought I was just freaking out from the blood or something, idk. But i, according to him, turned blue after he finally stopped. I was significantly higher the rest of the night. This was NOT all in my head. I would be interested in seeing a study about this. Idk if 'plasma levels' is even relevant here, just the first thing I could attribute to what happened. But I know it happened. So my opinion, based hopefully in science, is that you should use the least amount of water provided it's the hydrochloride salt you have as it is very soluble in water. Now #3 is a different story but around here in Ohio the rare occurrence of 3 is already cut with vinegar to make it soluble in H20. Hope this helps someone reading this old thread. *bump (that's the sound of my opinion hittin in the trunk, I'm evil morty and idgaF!)