MDPV Megathread 11: Still sorting all the porn.

[Albion]

MDPV​

Old thread here

Methylenedioxypyrovalerone (MDPV) is a psychoactive drug with stimulant properties which acts as a norepinephrine-dopamine reuptake inhibitor (NDRI). First developed in 1969, it remained an obscure stimulant until around 2004 when it was reportedly sold as a designer drug. It is also known as Cloud 9, MDPK, MTV, Magic, Maddie, Black Rob, Super Coke, PV and Peeve.

Methylenedioxypyrovalerone has no record of FDA approved medical use. Reportedly, it has four times the potency of methylphenidate (Ritalin, Concerta), although its pharmacology has only recently been studied in detail. MDPV is the 3,4-methylenedioxy ring-substituted analog of the compound pyrovalerone, developed in the 1960s, which has been used for the treatment of chronic fatigue and as an anorectic, but caused problems of abuse and dependence. However, despite its structural similarity, the effects of MDPV bear little resemblance to other methylenedioxyphenylalkylamine derivatives such as 3,4-methylenedioxy-N-methylamphetamine (MDMA), instead producing primarily stimulant effects with only mild entactogenic qualities.

The primary psychological effects have a duration of roughly 3 to 4 hours, with after effects such as tachycardia, hypertension, and mild stimulation lasting from 6 to 8 hours. High doses have been observed to cause intense, prolonged panic attacks in stimulant-intolerant users, and there are anecdotal reports of psychosis from sleep withdrawal and addiction at higher doses or more frequent dosing intervals. MDPV has been distinguished by some for its powers as an aphrodisiac. It has also been repeatedly noted for inducing strong cravings to re-administer. Users have reported a compulsive desire to continuously re-dose, even following onset of the unpleasant side effects induced by prolonged use and higher doses.

Extended binges on MDPV have also been reported to produce severe comedown syndrome similar to that of methamphetamine, characterized by depression, lethargy, headache, anxiety, postural hypotension (lightheadedness and weakness of the muscles), and in some cases severely bloodshot eyes, which usually subside within 4 to 8 hours. MDPV may also cause temporary bruxism or grinding of the teeth. Side effects are highly dose-dependent. No fatalities have so far been reported without the combination of other substances except for suicide.
Reported modalities of intake include oral consumption, insufflation, smoking, rectal and intravenous use. It is supposedly active at 3–5 mg, with typical doses ranging between 5–20 mg. MDPV loses potency when it is put into solution.​

 

[mydrugbuddy]

Subutex was prescribed as an antidepressant Fuck sake thats incredible, why not go the whole hog and prescribe pure heroin. Im sure that would have been even more effective. Freud did actually prescribe cocaine to his depressed patients. Yes it did cheer them up, but the longer term prognosis was not so good.

 

[Shambles]

Oopises. I meant Seroxat not Subutex - thanks for spotting my *ahem* deliberate mistake. I blame the drugs silly names drug companies give their products. That and subpar proofreading anyway

As it happens, Subutex actually has been prescribed for depression but never on a wide scale and mostly in the US (surprise, surprise). I think they were only pilot schemes though as - anecdotally - so many people prescribed bupe for addiction report that their depression is also relieved by it. I happen to agree cos it does seem to have an antidepressant effect but it's certainly not generally prescribed for that purpose and isn't what I'm prescribed it for. Although I actually did enquire with my GP once. And for ketamine which has similarly been trialed after anecdotal reports of antidep effectiveness. Again, very much not standard practice and never widespread. One fella used to post in OD who was on the ketamine pilot scheme though and he found it useful. GP said no chance when I (half-jokingly) asked. It did raise a smile though and he was interested to look up the reasearch.

 

[mydrugbuddy]

yeah its a damn fine AD, shame about the dependency and addiction and abuse profile though eh.

Wow, a Dr with a sense of humour. Jesus i must move back to from where i came, from all reports the drs around there seem to be far more understanding of such issues than inner city drs who are probably sick of seeing people with drugs problems. Thats the impression they give me at least.

 

[Shambles]

SSRIs have dependency and withdrawal profiles that rank with many opiates - at least in my experience. Definitely not the abuse potential though. Nor the effectiveness in my experience, unfortunately. Some are no better than placebo in studies from memory. But plenty peeps find they work a treat so whatever works for the individual really. I'm not really sure there can ever be a perfect purely chemical "cure" for depression - it seems to be a complex and intractable problem

 

[Si Dread]

I think you're right, & not enough research goes into psychological illness for us to know much about depression at all.

I'd have to be pretty Goddamned close to suicidal to go anywhere near anti-depressants these days! I'd rather use heroin!

 

[mydrugbuddy]

yeah the whole life circumstances thing for a start. Say if you were serving life in jail or something you'd probably not be feeling overly upbeat about that, i doubt any AD other than the abusable ones would alleviate such symptoms.

 

[StoneHappyMonday]

I'd have to be pretty Goddamned close to suicidal to go anywhere near anti-depressants these days! I'd rather use heroin!

And I'd prescribe MDMA. Sometimes LSD. Some diazepam. Depression is a spiral of straight thinking where negative interpretations are forced onto imaginary patterns. The depressed person needs to break that spiral, to be able to think in a different way. Like what a counsellor will do for you over 30 sessions and £900 the slow way around. I think fast track with E and Acid is an approach worth checking out. Drugs that alter the thinking space. But that don't shut it down like heroin. Obviously the use of such controversial drugs previously characterised as devil medicine would have to be done along with a huge campaign to change the public perception. Set and setting baby. But yeah, drugs that properly change mind space. Not ones like Prozac that take 6 months if they work at all. Another handy little profitable dependence building for big pharma.

MDMA, the best AD. In Nick Saunders "E for Ecstasy" - "I realized after taking E that the state I'd walked around in for years wasn't normal at all, or at least my normal had become a mild depression. Taking MDMA made me realize our natural state is actually the opposite of this. We should feel ecstatic."

 

[mydrugbuddy]

what happened when it wore off though ? Wasnt there a comedown experience where things seemed even worse than they did to begin with ? That was allways my experience. Great for the few hours of serotonin release and buzzing like fuck, and yes there were lingering good memories if it had been a good night, but the comedown was allways brutal for days afterwards, whether it had been an excellent night out or not.

Or do you mean taking it in more controlled, therapeutic doses ? Is that sustainable ? Wouldnt the brains serotonin just be rinsed out leaving you dry of feel good chemicals ?

 

[StoneHappyMonday]

Controlled therapeutic doses and moderation. Comedowns are not inevitable but another cultural exaggeration cum self-fulfilling prophecy. And teaching what goes up must come down, but being taught to see that as part of a whole, might just give the user/sufferer a more helpful perspective to begin with.

Im not saying MDMA is the total tool. But I'm convinced it could be of help to the majority with the right set and setting.

 

[mydrugbuddy]

it can certainly break down barriers between people. Im sure interpersonal problems or lack of good interpersonal relationships are a major contributor to depression. In that sense you are on to something.

 

[StoneHappyMonday]

The sheer number of people who say it changed their life and helped cure their social anxiety is anecdotal evidence enough to persuade me of the medical benefits of MDMA.

 

[Ben So Furry]

When does my treatment start Doc?

 

[Shambles]

I count myself as an MDMA success story. Whether it is the case or not it certainly seemed that way to me. I really didn't know what empathy was until I took MDMA "properly" (I had prior experience of simply getting fukked on it but only in conjunction with other drugs or as part of some stupidly OTT binge). I never notciced any comedown. I do notice a period of reflection and not being high any more and feeling a bit tired and craving a cuppa sweet tea and perhaps a biccy or two. That's about as far as "comedowns" go for me with MDMA. I'd like to think some of the empathy and connection to others lingers though.

It was originally suggested for use in couples' therapy by Shulgin himself and it was apparently rather successful. Also been used successfully for PTSD and certain forms of counselling - often related to chronic disease with a less than bright prognosis. Psilocybin has been used for the same things (aside from PTSD which I suspect would not be such a great idea for a psyche).

That aside, any chance of a new peev thread, modbuddies? Post 1013 no less. You just can't get the staff these days 8)

 

[Ben So Furry]

Been thinking about PV a lot lately. Nt sure why it's been more than a year since I last used. It was going great tbh. Bit shitty to start with but lately I just want the have a massive toot off foil. I mean it's good, I wont order anything or anything daft like that. Too much to loose now.

Just weird lately craving again.

 

[foolsgold]

The sheer number of people who say it changed their life and helped cure their social anxiety is anecdotal evidence enough to persuade me of the medical benefits of MDMA.

methoxetamine need crediting with same zeal as mdma does by these people

il say the same as most mdma changed me

 

[Shambles]

Been thinking about PV a lot lately. Nt sure why it's been more than a year since I last used. It was going great tbh. Bit shitty to start with but lately I just want the have a massive toot off foil. I mean it's good, I wont order anything or anything daft like that. Too much to loose now.

Just weird lately craving again.

Goody-good. Somehow I can't imagine peev would mix so well with cheffing. Suspect there'd be a bit of an excess of "Chef's Special Sauce" in every order that week

Great to see ya back around the place, not so great to hear you're still getting cravings but maybe not a complete surprise - we all know about those

But back to greatness in your keeping a lid on it. Just don't let it boil over

*gets coat, leaves before the urge to go on a chef/peev poor quality punfest becomes too strong*

 

[Ben So Furry]

Thank you Shambles. It wont amount to anything just odd I feel like this after all this time.

I did go into work once while peeved up to the gills. Was horrible I was constantly looking over my shoulder or through the windows to catch the folk who definitely were watching me out. Listening for what folk were saying about me. You're right it doesn't mix at all.

Funnily enough I once went to three job interviews in the same day after a whole night in PV land. I thought I was a wobbly, smelly, incoherent wreck but I got offered all three. Fucking insane.

Peev runs are best suited to a locked dark room kept out of any extreme daylight and without doubt without real human interaction. Unless its a sex session. As long as it's quick so I can get back to vaping. Cheers.

 

[hexagram]

fuck it i'm getting some pv.

all this talk about it has made me too curious, need to see what it's actually like.

 

[Shambles]

Hmm... that's not quite the intention of this thread, Hex. You may want to take a bit of time to read back through a couple of the prior ones cos despite the proclamations of undying for the stuff that pepper the place they are greatly outweighed by the trouble the stuff causes to just about all in its wake. The risks are very real indeed and they often come to fruition from the first time of use onwards. It's about as extreme and experience as drugs can provide - and that isn't meant as an advertisement. One to be properly researched before even thinking about going near any "Confirm Order" buttons. You will be glad you did whether you decide to order in the end or not cos it's a bit of a tricksy beast to say the least. Tricksy as in weeks of psychosis and the like.

When it comes to MDPV, forewarned absolutely is not forearmed... but it helps.