I'm interested what we know about benzo tolerance in people like me with a history of long term benzo addiction (approx 15 years), followed by detox. After detox I didn't touch any benzo for about 6 months, but when I did, I noticed that I required considerably higher doses than someone without tolerance. This was after being 6 months totally without benzos after detox.
Does benzo tolerance ever disappear, if you have been physically addicted? Is the brain wired to instantly "recognize" benzos even long after you've quit using them (even many years after using them). Is the action of GABAA permanently altered by long term benzo use? In other words, is GABA receptor down-regulation from benzos permanent or reversible?
Have there been studies done about this?