First a couple of axiomatic statements:
Common stimulants such as methylphenidate and Amphetamine exert their effects predominately by increasing extracellular dopamine levels in the brain, albeit through different methods.
In 2011, Hugo Lövheim proposed a model of emotion in which all basic emotions can be modeled as functions of three pre-eminent monoamines: Serotonin, dopamine and Norepinephrine. Pictured below.
Joy, or euphoria is then a result of increased dopaminergic and serotonergic activity.
In support of this Cocaine, perhaps the paragon of all euphoric stimulants is in fact a triple re-uptake inhibitor rather then simply working through DA and/or NE.
SSRI's are well known to increase the extracellular levels of serotonin in the brain.
So then should co-administration of the aforementioned dopaminergic stimulants and an SSRI not give a more euphoric effect then the stimulant alone? Is this an oversimplification of the processes going on or have i started from one or more false axioms? And yes caution should be taken given the risk of serotonin poisoning, any dose of an ssri should be small in this scenario to help mitigate this risk.
I'd appreciate any thoughts and comments and of course the moderators' tolerance of my uncertainty whether this query should be classified advanced or basic.