This is not a thread about "my tolernce" and "what's wrong with me". Mods know...just wanted to get that out of the way. That said, myself and others I know have built a permanent 'tolerance' to Opioids. Months with zero exposure and I(we) would still have to take considerably large amounts of whatever was on hand at the time. This has been a factor for nearly two to three years now for myself.
1. Could it be a Psychological phenomena that occurs, thus causing you to literally stop euphoria subconsciously?
2. Is it possible that continued use of the P.S. family's milk affectively deteriates/damages the receptors, mainly the nerves, causing dead nerve endings unable to regenerate? Considering neuro-transmitters inform you brain of all things percievable, their damage could put a halt to the party, I would think.
3. Similar to #2, except more of a combination of exposure and natural cell degeneration. the mu receptors are quick to go with age or are they one of the last things to go? The elderly on their death beds get pumped with Opiate/Opiod medications that seem to be accepted easily. God knows at that point it's probably the best shit you'll have.
So, has anyone read anything regarding the receptors life cycle and durabilty and is anyone else at that point of what I consider "permanent tolerance"? Is it common or uncommon? I can drink like a fish as well and am currently on a Tram ride that cost me a bit more than the max warning for seizure threshold. I've exceeded many times with no issues. Tram is actually more effective ,proportunately speaking, than most Opes. Just curious about my questions. I just thought to post them in an instant, so forgive me if there is already a thread of this nature(I somewhat doubt that) and that I havn't done enough of my own research on the subject yet. I'll do that now.....Peace. AdNeuro