Welcome to the Diphenidine Thread
Diphenidine is a novel dissociative anaesthetic drug with mild stimulant potential and a large amnestic component, making it relatively easy to feel like you black out during the experience, unable to recall what has happened. This also suggests there may be a potential risk of losing control over one's behavior. Always start with a very low dose and slowly work your way up. The dose-reponse curve can apparently be quite steep and another individual may react quite differently to it, needing a different dose; especially since (cross)tolerance developed to NMDA antagonists / dissociatives drugs can be chronic!
Diphenidine is unusual because it is not an arylcyclohexylamine like most other dissociatives such as ketamine, PCP and their analogues. If you have tried this drug, please write a trip report and submit it in the trip reports forum of Bluelight, or here in this thread and we will move it for you. This drug does not seem to have a long history of use in humans at all and we can use all the information on it there is.
- 107 mg Diphenidine Report - "Floating in a pleasantly soft liquid"
- 115 mg Diphenidine Report - "Caught up in the clouds"
Brief effect summaries for the TL;DR generation
- 50 mg summary by latest
- 100 mg summary by latest
- 110 mg summary by latest
- 150 mg summary by latest
- 110 mg + 50 mg summary by Dioxy
- general summary and notions by Sepher
- general summary and notions by Jesusgreen
Research article covering in vitro pharmacological properties of this compound
So a certain vendor has released this to its advanced customers. Its meant to be an NMDA antagonist so that means it could have effects similar to MXE/Ketamine if im not mistaken?
From the website:
Anyone got any ideas on what this would be like? Whether it will be a decent chemical or a waste of time?What is Diphenidine?
Diphenidine / DND / 1,2-DEP is a new research chemical which has been developed in 2013 by our own laboratory. Due to the nature of its chemical structure, the activity of this molecule is comparable to other NMDA antagonists such as ketamine but it’s chemical structure is new.
What is 1,2-DEP used for ?
Diphenidine / DND / 1,2-DEP acts as an antagonist at the NMDA receptor and is also acts on the dopamine transport, inhibiting the reuptake of dopamine. Based on this, it is useful to researchers for in vitro modelling of NMDA & Dopamine transport interaction. Researchers may also use Diphenidine as a reference sample for their GC/MS, FTIR or NMR analysis catalogue.