These aren't commonly referred to as opiate potentiators, and for those who would maybe like to investigate, it seems they theoretically should significantly prolong the high. However, I am in a different situation....
I have an amount of chronic anxiety (which is being treated with gabapentin and a benzo). I usually only can tolerate half a cup of coffee and that's enough stimulation for me.
I have been taking oxycodone for pain and am getting ready to kick and am looking into this (either DPA or DLPA) as maybe being something to help.
I've read anecdotal reports (I can cite if you want, but a quick google will show you) of this helping methadone users and some 'normal joes' with chronic pain and 'mood lift' and keeping an 'elevated mood'. Here is some info for people not familiar with DPA and DLPA:
"D and DL--Phenylalanine (but not L-Phenylalanine) inhibit several enzymes which are responsible for the destruction of the body's pain-killing hormones, including Carboxypeptidase A and "enkephalinase" en-zymes. With these enzymes inhibited, the brain's own naturally-produced endorphins enjoy a longer life span, and are thus able to exert their powerful pain-relieving actions for long periods of time."
Now, here are my main questions:
1. L-Phenylalanine (LPA) is converted into L-tyrosine. L-tyrosine in turn is converted into L-DOPA, which is further converted into dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline) all stimulatory neurotransmitters which, I obviously don't want being in withdrawal and also as an anxious person. However, does the presence of LPA in dLpa actually contribute to a psychological response?
2. "Also, as DL-phenylalanine inhibits endorphin degradation, this leads to an inhibition of GABA release in the ventral tegmental neurons (in the midbrain), which results in greater dopamine release. This can explain the analgesic effects following ingestion." Dopamine, and correct me if I'm wrong, is stimulatory in nature. However, for someone in withdrawal, the 'feel good chemical' may be helpful it seems...?
3. As referenced above, I think an inihibition of GABA is again, not the best for someone with anxiety/withdrawal. Would anyone privy to pharmacological/neurobiology care to comment?
MODS: Feel free to move this to ADD...