As a pain patient who has started to develop a tolerance to my 10/325 percocets (every 6 hours), I have a few questions.
I am also prescribed hydroxyzine in 25mg caps. I know that hydroxyzine, like other 1st generation anti-histamines, inhibits CYP450 2d6 (among others).
It is my understanding, that oxycodone is metabolized to oxymorphone (among other metabolites) by 2d6, meaning that, if inhibited (albeit somewhat weakly) by hydroxyzine, analgesic effect will be lower as oxycodone is weaker than oxymorphone.
However, I've seen very frequently that people say to take hydroxyzine with or shortly before taking opioids (somewhere I saw an alleged 50% increase in effect).
Now, can anyone address these issues? Anyone have personal experience with hydroxyzine and oxycodone SPECIFICALLY?
Thanks.
I am also prescribed hydroxyzine in 25mg caps. I know that hydroxyzine, like other 1st generation anti-histamines, inhibits CYP450 2d6 (among others).
It is my understanding, that oxycodone is metabolized to oxymorphone (among other metabolites) by 2d6, meaning that, if inhibited (albeit somewhat weakly) by hydroxyzine, analgesic effect will be lower as oxycodone is weaker than oxymorphone.
However, I've seen very frequently that people say to take hydroxyzine with or shortly before taking opioids (somewhere I saw an alleged 50% increase in effect).
Now, can anyone address these issues? Anyone have personal experience with hydroxyzine and oxycodone SPECIFICALLY?
Thanks.