Scrofula
Bluelight Crew
- Joined
- Apr 27, 2017
- Messages
- 5,399
OK, your PMID 14578014 still returns a 404 from Wiley. Yes, the abstract is good, I just get a sad when an open-access paper turns out to not be there.
Now, the study you think is about PAWS is of course, not at all about PAWS if you read the abstract. For one, PAWS is not a medically recognized condition, just a vaguely defined set of possible emotional labilities that may come with abstinence. And, this says more about the psychology of dependence than it does about the med.
Oh, and I know it's simple for you, after all the nootropics, but as it says in the first line, their reason for the study was the conflicting results for research on your miracle benzo cure:
Here's what they did: they took some "patients" who were once dependent on benzos, but have been abstinent for at least 47 weeks. Meaning, they are not in withdrawal, and they are not in PAWS, because there's no output for that. Like taking ten alcoholics, all of whom have been sober for two years.
They dosed them, the "patients" because that's a convenient term, and "controls", because that's easier than "normal people who never got hooked on xannies/k-pins/eties/triazoloeties" with either saline or flumazenil, thus inducing a withdrawal-like syndrome. In everyone. Because it's an antagonist. No one was in withdrawal when it started, post acute or otherwise.
Here's what they found: numbers are skewed in other studies because the former benzo addicts were all especially bitchy to begin with. They were aggressive and hostile when sent into withdrawal with the first shot, more than the controls. At least, that's for the saline shot. That's right, when former benzo dependents just thought they were being given an "anti-benzo" they got terribly aggressive and hostile.
When they got flumazenil, they started off aggressively, but calmed down to control levels around four shots in. They might have had a taste of some partial agonism at diverse receptor sites.
The conclusion there is that your own mind is responsible for a lot more of the withdrawal symptoms you experience than you want to believe, and from a purely stats perspective, ignoring context, you could make the argument that genuine shots of flumazenil are better for made-up symptoms than placebo shots for the same thing, when you're already a benzo addict with neuroses about benzos.
I don't support that kind of bullshit used as argument though.
.
I see a greenlighter oblivious to his many warnings. Of course doctors have been prescribing this for years, did I not just say its FDA approved, been around for a while, used routinely for post-operative waking? What it's not approved for is oblivious suburbanites with PRN Xanax scripts and their thieving grandchildren who got themselves hooked, started ordering online and now can't quit cold without seizing. And the folks with anxiety disorders who tried some benzos a few times, until they were taken in by trolls who led them to fresh delusions about side effects benzos just don't have, and online con-men who try to sell them snake oil cures.
How does that equal excessive daytime sleepiness, Oh hyper-aware one? How does narcolepsy enter in to this, unless you want a script for yourself that works so you can still sell your Dexedrine to your classmates? I'll admit I haven't seen ABC news or any TV in a long time, or I'd know, like every one else. Alas, I'm merely a mod of a drug forum, with no life and stims, who spends like 14 non-masturbating hours a day reading up on which drugs folks are putting up their butts lately (gabapentin, btw).
No one has discovered that flumazenil works wonders for their benzo withdrawal symptoms, but their insurance won't cover that unapproved use so they turn to the dark web to order it. They do it for diarrhea medicine, they'd do it for this. Thus, no one outside the rare Italian clinic.
So enough of the hypersomnia. We're inducing it in others.
Now, the study you think is about PAWS is of course, not at all about PAWS if you read the abstract. For one, PAWS is not a medically recognized condition, just a vaguely defined set of possible emotional labilities that may come with abstinence. And, this says more about the psychology of dependence than it does about the med.
Oh, and I know it's simple for you, after all the nootropics, but as it says in the first line, their reason for the study was the conflicting results for research on your miracle benzo cure:
The benzodiazepine antagonist flumazenil has reduced, increased or not affected hostility and aggression in animal and human studies
So, which of those three is most correct?Here's what they did: they took some "patients" who were once dependent on benzos, but have been abstinent for at least 47 weeks. Meaning, they are not in withdrawal, and they are not in PAWS, because there's no output for that. Like taking ten alcoholics, all of whom have been sober for two years.
They dosed them, the "patients" because that's a convenient term, and "controls", because that's easier than "normal people who never got hooked on xannies/k-pins/eties/triazoloeties" with either saline or flumazenil, thus inducing a withdrawal-like syndrome. In everyone. Because it's an antagonist. No one was in withdrawal when it started, post acute or otherwise.
Here's what they found: numbers are skewed in other studies because the former benzo addicts were all especially bitchy to begin with. They were aggressive and hostile when sent into withdrawal with the first shot, more than the controls. At least, that's for the saline shot. That's right, when former benzo dependents just thought they were being given an "anti-benzo" they got terribly aggressive and hostile.
When they got flumazenil, they started off aggressively, but calmed down to control levels around four shots in. They might have had a taste of some partial agonism at diverse receptor sites.
The conclusion there is that your own mind is responsible for a lot more of the withdrawal symptoms you experience than you want to believe, and from a purely stats perspective, ignoring context, you could make the argument that genuine shots of flumazenil are better for made-up symptoms than placebo shots for the same thing, when you're already a benzo addict with neuroses about benzos.
I don't support that kind of bullshit used as argument though.
.
I see a greenlighter oblivious to his many warnings. Of course doctors have been prescribing this for years, did I not just say its FDA approved, been around for a while, used routinely for post-operative waking? What it's not approved for is oblivious suburbanites with PRN Xanax scripts and their thieving grandchildren who got themselves hooked, started ordering online and now can't quit cold without seizing. And the folks with anxiety disorders who tried some benzos a few times, until they were taken in by trolls who led them to fresh delusions about side effects benzos just don't have, and online con-men who try to sell them snake oil cures.
How does that equal excessive daytime sleepiness, Oh hyper-aware one? How does narcolepsy enter in to this, unless you want a script for yourself that works so you can still sell your Dexedrine to your classmates? I'll admit I haven't seen ABC news or any TV in a long time, or I'd know, like every one else. Alas, I'm merely a mod of a drug forum, with no life and stims, who spends like 14 non-masturbating hours a day reading up on which drugs folks are putting up their butts lately (gabapentin, btw).
No one has discovered that flumazenil works wonders for their benzo withdrawal symptoms, but their insurance won't cover that unapproved use so they turn to the dark web to order it. They do it for diarrhea medicine, they'd do it for this. Thus, no one outside the rare Italian clinic.
So enough of the hypersomnia. We're inducing it in others.
