So a friend of mine has Crohn's disease and currently takes 12.5 mg of Methotrexate every Sunday. We will be attending a New Years rave, and he wants to try MDMA for the first time. I've been watching out for him, and doing some research to see if the two drugs (MDMA and Methotrexate) would interact to produce harmful effects, and it seems like the only problem would be the strain placed on the liver. However, if the mdma is taken sublingually (under the tongue), it completely bypasses the liver/stomach and goes straight into the blood stream. Also, the rave is on a monday, the day after he takes his medication. Would there be any complications for him if he took a small dose of mdma sublingually for his first time? I talked to him about plugging, and he really doesn't want to do it. Thanks for any input you may have!