Sherminator
Bluelighter
- Joined
- Aug 18, 2011
- Messages
- 70
Cyproheptadine (<http://en.wikipedia.org/wiki/Cyproheptadine>)…I recently became interested in this unusual antihistamine compound when researching possible ways to counteract the sexual side effects of SSRIs (specifically Lexapro). It appears to be a potentially very interesting substance, and the only discussion I could find on it on blue light was a brief BDD thread about its anticholinergic deleriant effects. It appears that this compound can treat SSRI induced sexual disfunction, and also has some other interesting properties
Wikipedia's claim that it can treat SSRI-induced sexual dysfunction is backed up by several papers I found on pub med, a quick search there can bring them up.
Also backed up by academic papers on pub med were the claims that it can be used to treat serotonin syndrome, which might make it an essential harm reduction tool to have on hand for anyone using drugs that could possibly result in SS, much the same way narcan is useful for any opiate user to have around
This made me wonder if Cyproheptadine's 5ht2a/ 5ht2b/ 5ht2c antagonism could make it a useful tool for coming down from serotonergic psychedelics (mushrooms, LSD, 2C-x, for example) or from MDMA. Could this drug possibly be effective at stopping a bad trip. I also wonder if its antagonism at 5ht2c could be the reason for Cyproheptadines's appetite stimulant effects and reduction of vomiting. Speaking of which:
It is also an appetite stimulant and can reduce vomiting, which seems to be an important medical use, as well of use to drug users. Stimulant users could combat the lack of appetite induced by their drug of choice (such as meth or cocaine). Antihistamines in general are known to be good in combination with opioids, they cause sedation, reduce the itching caused by opioids, and in the case of cyproheptadine may be very effective in reducing opiate-related nausea and vomiting. It could also kill the nausea caused by many psychedelics (in my experience 2C-E and 5meo-MiPT were the worst) though it might kill the rest of the trip along with the nausea.
It is also apparently a very good sleep aid. This site: http://www.news-medical.net/health/Insomnia-Treatment.aspx states that, "Cyproheptadine is a useful alternative to benzodiazepine hypnotics in the treatment of insomnia. Cyproheptadine may be superior to benzodiazepines in the treatment of insomnia because cyproheptadine enhances sleep quality and quantity whereas benzodiazepines tend to decrease sleep quality." It also can reduce nightmares, especially in PTSD sufferers, according to wikipedia.
This compound has many other interesting effects, for example, reducing sweating, a possible benefit to drug users who take things like MDMA, amphetamines, or cocaine, that cause excessive sweating.
I was wondering what your thoughts on this drug are, and is it as useful to drug users as it appears from my brief research? I may be asking my psychiatrist to prescribe me this to combat the sexual effects my Lexapro prescription has been giving me, as it has been working great for my depression and anxiety and these are the only side effects I have had from it. It would also be nice to have on hand for drug related benefits, such as combining with opiates or for stimulant comedowns.
Wikipedia's claim that it can treat SSRI-induced sexual dysfunction is backed up by several papers I found on pub med, a quick search there can bring them up.
Also backed up by academic papers on pub med were the claims that it can be used to treat serotonin syndrome, which might make it an essential harm reduction tool to have on hand for anyone using drugs that could possibly result in SS, much the same way narcan is useful for any opiate user to have around
This made me wonder if Cyproheptadine's 5ht2a/ 5ht2b/ 5ht2c antagonism could make it a useful tool for coming down from serotonergic psychedelics (mushrooms, LSD, 2C-x, for example) or from MDMA. Could this drug possibly be effective at stopping a bad trip. I also wonder if its antagonism at 5ht2c could be the reason for Cyproheptadines's appetite stimulant effects and reduction of vomiting. Speaking of which:
It is also an appetite stimulant and can reduce vomiting, which seems to be an important medical use, as well of use to drug users. Stimulant users could combat the lack of appetite induced by their drug of choice (such as meth or cocaine). Antihistamines in general are known to be good in combination with opioids, they cause sedation, reduce the itching caused by opioids, and in the case of cyproheptadine may be very effective in reducing opiate-related nausea and vomiting. It could also kill the nausea caused by many psychedelics (in my experience 2C-E and 5meo-MiPT were the worst) though it might kill the rest of the trip along with the nausea.
It is also apparently a very good sleep aid. This site: http://www.news-medical.net/health/Insomnia-Treatment.aspx states that, "Cyproheptadine is a useful alternative to benzodiazepine hypnotics in the treatment of insomnia. Cyproheptadine may be superior to benzodiazepines in the treatment of insomnia because cyproheptadine enhances sleep quality and quantity whereas benzodiazepines tend to decrease sleep quality." It also can reduce nightmares, especially in PTSD sufferers, according to wikipedia.
This compound has many other interesting effects, for example, reducing sweating, a possible benefit to drug users who take things like MDMA, amphetamines, or cocaine, that cause excessive sweating.
I was wondering what your thoughts on this drug are, and is it as useful to drug users as it appears from my brief research? I may be asking my psychiatrist to prescribe me this to combat the sexual effects my Lexapro prescription has been giving me, as it has been working great for my depression and anxiety and these are the only side effects I have had from it. It would also be nice to have on hand for drug related benefits, such as combining with opiates or for stimulant comedowns.
