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The Big & Dandy 25I-NBOMe Thread (3rd edition)

What [b]in your experience[/b] would be a maximum responsible buccal dose for 25I?

  • up to 500 μg

    Votes: 9 8.1%
  • up to 750 μg

    Votes: 17 15.3%
  • up to 1000 μg

    Votes: 32 28.8%
  • up to 1500 μg

    Votes: 30 27.0%
  • up to 2000 μg

    Votes: 14 12.6%
  • a dose higher than 2000 μg

    Votes: 9 8.1%

  • Total voters
    111
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Wait, you've made a snortable powder using beta-Cyclodextrine and it's not working that intensely even after 3mg? Seems to me that the 25i is not evenly distributed, especially considering the discrepancy between your 2 25c dosages.

If I got this part right do NOT take this powder again, you could actually die if there is too much in a single spot

For me 25i is already very active at ~500ug (though a bit lacking, the real fun starts at ~1mg), so yeah, be cautious. 25c should already be active at 250ug or so..
 
No it was intense after 3mg but that was as the previous person suggested that was after re-dosing, waiting and redosing. I've checked with a few official pharmaceutical guides to different methods of creating a complex with betacylodetrin for this very reason that I didn't want to use one of the cheaper more accessible options of an excipient like lactose and then have the possibility of hot spots (uneven distribution). I followed an official pharmaceutical guide for making a complex with betacylodextrin. The best small scale way was to make a paste gradually and work it thoroughly in a mortar and pestle for an 1hr. I worked out the molar masses before hand and made sure the beta cylodextrin was in excess. I double checked the calculations with those in the advanced drug discussion. I did this as well as checking with my pharmacist friend along the way. The complex is stored flat in a paper flap, just incase any unmixing max happen in just a plastic baggie. So far each of the 10mg (1mg active 25I) snorted dosages has had the same effect. I think it's safe to assume the complex is evenly distributed.

I also have a portable blood pressure & heart rate meter which I used throughout the experiment. I also have alprazolam and beta blockers if need be. I also have on hand nitro-glycerine tablets if severe vasoconstriction becomes a problem such as limbs turning blue or hypertensive crisis.
 
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Well, it's not the first time someone needs extreme dosages for effects of a substance... I assume you waited at least 2 weeks between your 25i and 25c trips for tolerance?

Now, I don't find that second redose on 25c being much more intense all that weird. The day I got the 25i I dosed ~500ug and had a pretty held back trip, then the day after that I redosed with the same amount and had a trip infinitely more intense. Each and every time after that the effects have been consistent with the dose (which is somewhere in the middle between those 2 times) There's something really off about this behavior, so if I were you I'd be a bit more cautious about dose-range and redosing. You never know what might happen with this and there is always a next time!

p.s Now that's some proper technique. Care to give a link to one of those guides? Could be useful one day :)
 
I waited a year between experimenting with 25C and 25I so there was no cross tollerance. Come to think of it I think it's been over a year since I had any real psychedelics (apart from say 6-apb which I take in fairly low dose and although it does give me some mild visual effects sometimes, I wouldn't class it as a true psychedelic it's more of an empathogen/entactogen with some mildly trippy effects.

Here is the technical guide I found most useful for making a betacyclodextrin complex. http://online1.ispcorp.com/Brochures/Pharma/CavamaxBulltn.pdf Look on page 7 for the different methods of preparing a complex. For the small scale lab without specialised equipment it recommends the -Paste Complexation or Kneeding- method. Now you'll need to check what the mole ratio is for making a complex I think from memory it maybe 1mole of active to 1 or 2 moles of betacyclodextrin. I've been told that if you have an excess of betacyclodextrin in this mole ratio it just makes things safer for a good mix. So I'd recommend always working it out with an excess of betacyclodextrin by mole mass ratio (not milligram to milligram ratio). I found a mini mortar and pestle worked a treat for so you can salvage as much of the dryed paste/powder from it fairly easily. These are those $5 ones you can buy from ebay in china. I added small amounts of distilled water to make a paste or almost a thick solution or suspension. As I worked the mortar and pestle over the hour it gradually dried up and I needed to add a few more drops of distilled water. In the end I scraped it up with a razor hobby knife and after letting it dry thoroughly I crushed the powder and mixed it very thoroughly. Now the final step I choose to do may not be necessary. I heard a rumour somewhere that there can be electrostatic charges in a standard plastic baggie that can unmix certain mixed powders or at least cause then to cling to the sides in an uneven fashion. Who knows maybe this is hogwash but what I do is once I've thoroughly mixed my dried complex powder I make a mini envelope from gloss magazine paper (they are called a flap in North America and various powders sold on the street come in them). I keep the envelope then inside a baggie.

Here is something important to consider if you are unfamiliar with minimum weighable mass... Basically the minimum amount of active (NBOMe family in this case) you can weigh accuratly for making into a complex.
According to proper lab weighing procedure the minimum weighable mass of a milligram scale (a scale that weighs down to 0.001g and has a standard fluctuation in either displaying +/-1mg) is 20mg. So 20mg weighed on those scales is called the minimum weighable mass because it's to be within 95% accuracy (ie. it could be between 21mg to 19mg). If you are weighing 10mg on those scales then the accuracy becomes 90%. Now if you are weighing on cheap milligram scales that displays a fluctuation of +/-2mg then your minimum weighable mass becomes 40mg to get the 95% accuracy. If you weighed 20mg on those scales with +/-2mg you'd be getting 90% accuracy. Continue this simple mathematics if your scale displays a fluctuation of +/-3mg to work out your minimum weighable mass and accuracy of the total. Also highly recommended I find using calibration weights. The set I got was 20bucks or less inc shipping from ebay. Get a set that has tiny milligram weights of 10mg or 20mg (I've noticed 50mg or 100mg calibration weights can be off by a couple of milligrams). This way you get an idea how accurate your scales are.

Many people like to use hydroxypropylbetacyclodextrin (HPBCD) as it's properties are better than betacyclodextrin (I can't remember exactly but I think its more soluble or it has a higher bonding ratio). Anyway from my looking into it HPBCD is more expensive and standard betacylodetrin is good enough for my purposes. Basically I found HPBCD and betacyclodextrin both a bit tricky to find for sale without a permit/account at a pharmaceutical/chem supplier (which for your purposes would be extremely dodgy trying to explain). Anyway after much searching I found a RC vendor I'm familiar with sold betacyclodextrin all along!

I ended up making my complex with 26mg of 25I so the accuracy percent should be pretty good. Now the end product I just weight up and snort 20mg of substance for 2mg of active 25I. The betacylodextrin goes well up the nose too.

If you are unsure about what you are doing don't attempt to make a complex! Even worse and much more risky is a simply mixing of NBOMe family active with an excipient (filler) which I've been told can mix unevenly and leave hotspots besides. If you do make a complex please double check your stoichiometry and maths with someone else who is knowledgeable. Once you've made your complex start low!! We already know from one Erowid user mistake that 30mg (and eaily less) is enough to cause siezures followed by cardiac arrest and then death, unless resuscitated which thankfully this person was and lived to tell the tale.



On another topic would anyone experienced in the NBOMe family and the 2C-x family be willing to submit their ideas as to how they rate them in terms of the depth of psychedelic nature of the trip? I just don't know if 25C or 25I really has much depth to it like a good solid trip on 2C-E or even possibly 2C-I (which is even less deep than 2C-E). Although I've not yet tried 2C-P I would guess based on SAR and anecdotal reports it's probably even more potent and deeply psychedelic/therapeutic than 2C-E (which has been my favourite for phenethylamine deep enchanting trips).

What are your thoughts? I've done many trips on the deeper more profound 2C-x's (2C-E, 2C-I) and quite a number of trips on the light/less profound of 2C-x's, (2C-B, 2C-C, 2C-D)

I've only done a handful of trips on 25C and of those only 2 where at a dose where it was really visual and properly immerse. I've only done one trip on 25I and thankfully the dose was right that I got the full experience of lots of visuals and feeling immersed in a trip. From my brief encounters with these 2 of the NBOMe family I can only say that think my mind was fairly empty and the trip seemed fairly direction-less. I think 2C-E and 2C-I took me more for a journey and I suspect these substances are more suited to deep psychedelic, analytical, psycho-spiritual exploration. Has anyone tried the main range of potent NBOMe's (25B, 25D, 25C, 25I) a number of times and can they compare if they were anywhere as deep/psychedelic as a good dose of 2C-E?
 
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ok take 2 of my experience with 25I

I took 1.5mgs about three hours ago (close to that, you know I cant remember that right now) and I still just cant really get behind this shit. I mean its cool, and defintely worth a look if you come across it, but my god I would never want to spend any amount of money for this. Its just..... not.....quite..... it

like I just dont see any reason why someone would be like "dude, were gettting FUCKED UP on 25i tonight!"

I guess I am enjoying it but god damn it leaves a lot to be desired

cinnamon helped with the vasoconstrict but now I got the taste of cinnamon in my mouth

its always something with this shit lol

and now I just have to convince myself I do actually like it until I can go to sleep and never fuck with it again
 
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