JackiesBabyy
Bluelighter
- Joined
- May 16, 2011
- Messages
- 595
promethazine blocks d2 receptors? According to wikipedia it does, and since opiate euphoria comes from dopamine, shouldn't that make it less euphoric?
Jackie I think its good that you're asking so many questions
As makes sense, there are multiple sub-types of dopamine receptors, not just D2. If I am right then D2 is supposed to be more stimulating (a typical anti-psychotic site), not as opiates. Furthermore, no functional person would have all of their D2 blocked - a drug only works on a portion of the nueron(s) it can affect. And finally, going along with this, promethazine and opiates work in different brain regions.
Euphoria is never just "from dopamine". There are many dopaminergic drugs which don't produce euphoria in much of the population.
Perhaps some opiate euphoria is negated by promethazine.
The potentiation mechanism wouldn't be by D2
How do you know this?it doesn't add to the euphoric nature of the opiate. in fact, it's put into codeine cough syrup to deter abuse as it prevents the liver from preventing codeine to morphine.
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Don't know if this helps at all, and it certainly doesn't answer the technical questions you have... But I have found higher doses of promethazine with codeine make me paranoid, depressed, anxious all at the same time. I get a general feeling of impending doom while at the same time exhausted???This is a bit off topic but still on... I have been taking norcos, about 3 or 4 at a time and I've noticed my sleep doesn't seem to be the same. I can easily fall asleep but i feel like i'm not cycling through all the stages like i normally would. I've noticed that drinking a few ounces or promenthazine with codeine about 2 hours before i go to sleep help with the problem. Is it just the difference in chemicals or possibly just the fact that the promenthazine makes me more tired? Does anyone have experience in this area? Recreationally, i don't notice much of an effect as far as euphoria goes after drinking the syrup but it could be that im not doing high enough dose or that my opiate tolerance is up.
Yeah, but doesn't pretty much every drug that causes euphoria/mood lifts affect dopamine in some way? (be it directly like amphetamines or indirectly like opiates/cannabinoids)
You know what, I don't necessarily get that from prometh and codeine alone but I feel that when I smoke cannabis and mix hydrocodone. Total paranoia but I'm assuming it's mostly the weed