messing with methadone and potentiation sounds like a good recipe for accidental death.
isnt the point for beingo n methadone not to get you high dude??? potentiating methadone is VERY VERY VERY dangerous even if you are on it for MMT. That said, have to respond to one post in that closed thread and I believe it was by Limpet. Limpet, if it was he, said he believed I might have been arrogant in commenting that the majority of BLers could not understand something. Sorry, burt BL is a Harm Reduction site, not a synthesis site and certainly not a chemsitry site. When this forum was iniated, after about a month or so of lobbying, the powers that be warned that it would probably provide alot of infromation that would be unfathomable to most BLers.
This not only has to do with the scope of the site, but in the overwhelming age of our members. If anyone cares to look into it they will find that most of our members are very young.essary to understand what was said but again, it is a good indicator. So, what I said was indeed the truth. It is not about pedestals, or arrogance, but rather a factual statement in terms of replying to the statement that "100 BLers" say "methadone is euphoric."Anyway, all that claptrap being finished, good post and thread TChort. It has been done to death on BL but nowhere nearly in depth as you are going and I like that alot.
People often make the assumption that similar subbstrates, and same enzymatic paths automatically lead to poetentiation. Inhibtion is a difficult thing for alot of folks but as a general rule, and it is a pretty relaxed rule, same and similar do the job. Methadone though has unique attributes in so many ways, and even so many ways within its metabolic path.
The flavanoids in grapefruuit juice, the subject you touched on in the other thread, being a prime example.
Fact is though, serum levels can be potentiated with methadone, as with just about any substance. The issue then becomes discernibility. Subjectivity is the overiding issue here. IF serum levels can be increased, and they can be in certain ways, then it all comes down to is it worth it because of effort and risks
Another issue I see is safety. I mean, with the ultra-heavy sedation methadone causes, combined with longest half life of any opiate/opioid, why bother? To increase sedation? How could you? To compensate....for...LACK OF EUPHORIA (hahah)? Now that IS a great reason but with the otherwise heavy pschoactivity taking place with methadone by itself ...
See, glutethemide potentiating codeine, or even promethezine potentiating codeine is something that will make a real difference on so many levels. Aside from the documented clinical facts there is an undeniable pschoactive component. Codeine on its own leaves alot to desire, yes? Methadone on its own also leaves something to be desired but in a much, much, much less discernible way.
Anyway, that is meandering from your point which is attemtping to verify potentiatos more than evalusating the utility of engaging them so mauybe it is a moot point here.