Ok, so lately I have noticed that one day I will take 1750mg which is 5 tabs of the amazing muscle relaxer, soma, and just get fatigue. It's missing that 'electric' feeling it has. then later I can take 700mg, and have the time of my life. I'm on just 700mg right now, and I have it all. Soma shakes/Shuffle, 'electric' feel that's pretty intense, barbituate-like feel, etc.
Does anyone know why Soma is a hit or miss? I know that Carisoprodol converts to Miltown in the liver so maybe my liver can convert it into that drug better if I drink something or take a vitamin that's liver-friendly?
Like fish oil vitamins, Thiamin, or Vitamin C.
That's interesting because that would imply it is not just a tolerance issue, since if it were tolerance it would just be getting gradually less effective over time as opposed to not working one day and working well the next. It could be due to factors such as what you eat, whether you take any other drugs, how recently you took Soma previously, etc.
By "Miltown" I assume you mean meprobomate - Miltown is a brand name for a drug containing mebromobate, it wouldn't be "Miltown" if the body converts carisoprodol into meprobomate as an active metabolite, but I realize I am just being nitpicky
. I'm not sure if the conversion to meprobomate is responsible for
all of the effects of Soma, but is definitely responsible for more of the "recreational" effects. To get your liver to convert more of it into meprobomate is not as simple as taking vitamins that are said to be good for the liver though. You would need something that specifically increases the enzyme that converts carisoprodol into meprobomate. Carisoprodol is metabolized to meprobamate by the enzyme CYP2C19. So you would want to take things that
induce this enzyme and avoid things that inhibit it.
One problem with using certain natural supplements to do this is that some induce CYP2C19 at low doses but inhibit it at high doses, so you would need to only take a low dose for those ones or else you could end up having the reverse effect to what you want - these include St Johns Wort and Ginko Biloba. Sage induces CYP2C19 (larger doses just induce it more) and valerian does the same thing but more weakly.
[Source]. So I would probably try sage or valerian.
If you are going to experiment with potentiating Soma please be careful and try a lower dose of soma than usual just in case it potentiates it a lot.
I have the same problem Its been years since I was able to do the soma shuffle all I get now is maybe some fatigue The next day...
Your problem does not sound the same, it sounds like you have just developed a tolerance, since it never works as effectively anymore for you. Tolerance to Soma can form very rapidly if you take it on a regular basis.