Guidelines issued by the UK-based National Institute for Health and Clinical Excellence (NICE), carried out a systematic review using different methodology and came to a different conclusion. They questioned the accuracy of studies that were not placebo-controlled. And, based on the findings of placebo-
controlled studies , they do not
recommend use of benzodiazepines beyond two to four weeks, as tolerance
and physical dependence develop rapidly, with withdrawal symptoms
including rebound anxiety occurring after six weeks or more of use.