All I want to know
All I want to know
Thank you kind sir,
The short answer is indeed a resounding yes however upon further investigation it depends on the trip inducing agent and the anti psychotic in question. Generally speaking anti psychs don't actually stop the trip but instead change its characteristics. Usually the experience will be somewhat dulled and often offer a more fatigued, stoned and less psychedelic adventure. In addition the effects may be shorter and in some cases the hangover or afterglow will be intensified.
If you have a particular agent and antipsychotic in mind let me know and I will expand further.
Serotonergic antagonists will prevent or stop a trip the most.
I think atypical antipsychotics like dopaminergic antagonists will prevent or stop a trip less but considering a 'wholesome' effect it will probably still be mitigated.
So as a simple answer: yes, because of the general neuroleptic effect. But some of them are more selective to 'reverse' or 'block' the actual psychedelic effect (mediated by 5-HT2A) and others work more by carpet bombing your total awareness.
The Pharmacology of Lysergic Acid Diethylamide: A Review
by Torsten Passie, John H. Halpern, Dirk O. Stichtenoth, Hinderk M. Emrich & Annelie Hintzen
CNS Neuroscience & Therapeutics 14 (2008 ) 295–314
This chart indicates that chlorpromazine (CPZ) will reduce the effects of LSD, and CPZ is a good indicator of how other phenothiazines might interact with LSD. However, I have heard that this effect does not extend to the atypical antipsychotics such a quetiapine (seroquel) -- which would most likely be designated as <--> if it were included in the chart above.
As an aside, I found it interesting that methamphetamine (MA) reduces the effects of LSD while amphetamine and methylphenidate increase the effects. This must be due to MA's significant 5-HT releasing effects, because 5-HT is a better agonist at 5-HT2A than LSD is.
my girlfriend has to take abilify/aripiprazol since january because of her mental condition. about a month ago we tried a low dose of acid together (100mcg), she did not feel any altered at all, while I was at a constant ++/+++
Yeah the meth bit is interesting, but I thought it didn't cause that much serotonin release. And it looks like LSD binds with slightly higher affinity than 5-HT, though they are similar. I'm guessing it's some quirk with that study.