I agree with some of that but its different for everyone.... For instance , Im prescribed 40mg ER's and and the 10mg IR's and by the grace of a Hi-er Power I still get the Old formula Octagon yellows Er's and pink 10mg Irs Also since this post is fairly new u should remove the Insufflation method since thats out the window with this crap new formula for those that have to suffer with them!!! Also its not 10x stronger than the other Oxy family members its 3x's stronger... Im sorry I'm not tryin to step on any toes but ive been on Oxymorphone for almost 5 years now and for those of you that think or even wanna try n "Boot" an OM-ER All I can say is DONT DO IT!!!! SWIM Did it and now he is a one armed bandit as we call me jokingly!! Sad but tru!! Now The IR's you can Bang all day according to SWIM but just be very careful or your gonna end up OD'ing so if u do, do small amounts a quarter of a 10mg pill should sufficie for u newbs! Just be careful ! I use them orally and im pain free all day!