Isopropylphenidate - longer or shorter acting?

[EncryptiC]

Few patents for treating ADHD etc. Also discussed briefly in this thread: http://www.bluelight.ru/vb/threads/362377-Ethyl-Ester-Analogues-of-DARIs

Ethylphenidate seems rather short acting (with long background/peripheral stimulation) , would the isoproyl be longer acting? Of course it would be a compound never tested in humans (unlike ethylphenidate which is a metabolic product of methylphenidate whilst alcohol is consumed). I guess the isopropyl removal might also represent a more toxic metabolie?

Any thoughts?

 

[DistyBoi]

Not sure about the chemical (never come across it before) but from inferences from similar isopropyl and phenidate compounds I would imagine the main difference would be acetone as a metabolite, it will probably follows first order kinetics and I expect the half life to be about 5 hours, as it should be greater than ethylphenidate by about 1-2x (which has a suspected half life of the same as its methyl cousin = ~3 hours)

 

[sekio]

All of the -phenidates will be fairly short acting due to ester hydrolysis.

 

[DistyBoi]

All of the -phenidates will be fairly short acting due to ester hydrolysis.

Do you mean phenidates in general, or that isopropylphenidate should have a shorter half life than ethylphen or methylphen?

I thought isopropyl esters tend to have higher potencies, longer duration and slower onset.

 

[sekio]

Well yes, in general as the ester gets more and more heavy the profile gets 'rounded out' and duration increases, but esters in general hydrolise much better than e.g. an oxazole or ether. If you were looking for a truly long lasting compound it would be best to dump the ester entirely (see: cocaine -> phenyl tropanes)